Microwave assisted regioselective synthesis and 2D-NMR studies of novel azoles and azoloazines utilizing fluorine-containing building blocks

被引：29

作者：

Al-Bogami, Abdullah S. ^{[1
]}

Saleh, Tamer S. ^{[1
,2
]}

Mekky, Ahmed E. M. ^{[1
,3
]}

Shaaban, Mohamed R. ^{[3
,4
]}

机构：

[1] Univ Jeddah, Dept Chem, Fac Sci, POB 80327, Jeddah 21589, Saudi Arabia

[2] Natl Res Ctr, Green Chem Dept, Cairo 12622, Egypt

[3] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt

[4] Umm Al Qura Univ, Fac Sci Appl, Dept Chem, Makkah El Mukarramah, Saudi Arabia

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2016年 / 1121卷

关键词：

Microwave irradiations; Azoles; Regioselectivity; Trifluoromethyl moiety; H-1-C-13; HMBC; ULTRASOUND PROMOTED SYNTHESIS; INHIBITORY-ACTIVITY; FACILE SYNTHESIS; DERIVATIVES; PYRAZOLES; IRRADIATION; ISOXAZOLES; CHEMISTRY; CATALYST; ESTERS;

D O I：

10.1016/j.molstruc.2016.05.064

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient regioselective synthesis of novel azoles containing a trifluoromethyl moiety via the 1,3-dipolar cycloaddition reaction under microwave irradiation, using fluorine-containing building blocks methodology was achieved. Furthermore, these novel azoles scaffolds have been employed as the starting material in the synthesis of new azoloazines containing a trifluoromethyl group. An unambiguous structural assignment of the obtained regioisomers was determined using the 2D HMBC NMR techniques as a valuable tool. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：167 / 179

页数：13

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