Synthesis and Characterization of Biodegradable Poly(ε-caprolactone)-b-Poly(L-lactide) and Study on Their Electrospun Scaffolds

被引:7
作者
Liao, Guiying [1 ]
Jiang, Kaifeng [1 ]
Jiang, Shengbin [2 ]
Xia, Hua [1 ]
机构
[1] China Univ Geosci, Fac Mat Sci & Chem Engn, Wuhan 430074, Peoples R China
[2] Hubei Res Inst Chem, Wuhan, Peoples R China
来源
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2010年 / 47卷 / 11期
基金
美国国家科学基金会;
关键词
Poly(L-lactide); poly(epsilon-caprolactone); block copolymer; electrospinning; fiber; SMOOTH-MUSCLE-CELL; IN-VITRO; DEGRADATION BEHAVIOR; EPSILON-CAPROLACTONE; BLOCK-COPOLYMERS; MORPHOLOGY; ACID); FIBERS; PROLIFERATION; NANOFIBERS;
D O I
10.1080/10601325.2010.511534
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A series of multi-block copolymers, poly(L-lactide)-b-poly (epsilon-caprolactone) (PLLA-b-PCL) were synthesized. The first step of the synthesis consisted of the transesterification between the PLLA and 1,4-Butanediol, followed by the copolymerization of PLLA-diols and PCL, using isophorone diisocyanate (IPDI) as a coupling agent. The synthesized polymers were characterized by Fourier transform infrared (FTIR) spectra, differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). PLLA/PCL block copolymers were electrospun into ultrafine fibers. The morphology of the electrospun fibrous scaffolds were investigated by Scanning Electron Microscopy (SEM). Results showed that the morphology and diameter of the fibers were affected by the electrospinning solution concentrationan and different weight ratio of PLLA/PCL. These electrospun PLLA-b-PCL fibrous membranes exhibited good flexibility and deformability. In comparison with the electrospun PLLA membrane, the electrospun fibrous membranes of PLLA-b-PCL demonstrated an enhanced elongation with still high tensile strength and Young's modulus to be beneficial for tissue engineering scaffolds.
引用
收藏
页码:1116 / 1122
页数:7
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