Ischemia-Modified Albumin and Inflammatory Biomarkers in Patients with Prostate Cancer

被引:14
作者
da Silveira, Rafael Arrua [1 ,2 ]
Hermes, Carine Lima [1 ,2 ]
Almeida, Tais Correa [1 ,2 ]
Bochi, Guilherme Vargas [1 ,3 ]
de Bona, Karine Santos [3 ]
Moretto, Maria Beatriz [2 ,3 ]
Moresco, Rafael Noal [1 ,2 ,3 ]
机构
[1] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Lab Pesquisa Bioquim Clin, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Ciencias Farmaceut, BR-97105900 Santa Maria, RS, Brazil
[3] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Farmacol, BR-97105900 Santa Maria, RS, Brazil
关键词
Ischemia-modified albumin; C-reactive protein; oxidative stress; inflammation; prostate cancer; ADENOSINE-DEAMINASE; OXIDATIVE STRESS; DISEASE; SERUM; ASSOCIATION; ACTIVATION; PLASMA; MARKER; LIPIDS; ASSAY;
D O I
10.7754/Clin.Lab.2014.131018
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Prostate cancer has become a public health problem in many countries and there is evidence which indicates that inflammation and oxidative stress play a key role in the pathogenesis of this disease. Thus, the aim of this study was to evaluate the concentrations of new biomarkers of oxidative stress, ischemia-modified albumin (IMA) and ferric reducing ability of plasma (FRAP), as well as the inflammatory markers in patients with prostate cancer. Methods: CRP, IMA, FRAP, fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, creatinine, albumin, AST, ALT, ADA, total PSA (tPSA), free PSA, and proportion of free PSA (fPSA%) were measured in 25 patients with prostate cancer and in 30 healthy subjects. Results: tPSA, CRP, and IMA were significantly higher in patients with prostate cancer. In contrast, fPSA% and FRAP were significantly lower in these patients. However, no significant differences were observed when IMA values were adjusted for serum albumin. Significant correlations were also observed for tPSA and CRP (r = 0.5104, p < 0.001) and for fPSA% and CRP (r = -0.5059, p < 0.001). Conclusions: We demonstrated that both inflammatory and oxidative processes are increased during prostate cancer and also that there is a reduction of antioxidant defenses in this pathology.
引用
收藏
页码:1703 / 1708
页数:6
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