The role of the central renin-angiotensin system in Parkinson's disease

被引:78
|
作者
Mertens, Birgit [1 ]
Vanderheyden, Patrick [1 ]
Michotte, Yvette [1 ]
Sarre, Sophie [1 ]
机构
[1] Vrije Univ Brussel, Dept Pharmaceut Chem & Drug Anal, Res Grp Expt Neuropharmacol, B-1090 Brussels, Belgium
关键词
angiotensin II type 1 receptor; antagonists; angiotensin II type 2 receptor; agonists; angiotensin-converting enzyme inhibitors; neuroprotection; Parkinson's disease; II TYPE-2 RECEPTOR; CONVERTING ENZYME-INHIBITORS; ROTENONE-INDUCED DEGENERATION; MESSENGER-RNA EXPRESSION; NADPH OXIDASE; DOPAMINERGIC-NEURONS; OXIDATIVE STRESS; AT(2) RECEPTOR; RAT-BRAIN; MICROGLIAL ACTIVATION;
D O I
10.1177/1470320309347789
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Since the discovery of a renin-angiotensin system (RAS) in the brain, several studies have linked this central RAS to neurological disorders such as ischaemia, Alzheimer's disease and depression. In the last decade, evidence has accumulated that the central RAS might also play a role in Parkinson's disease. Although the exact cause of this progressive neurodegenerative disorder of the basal ganglia remains unidentified, inflammation and oxidative stress have been suggested to be key factors in the pathogenesis and the progression of the disease. Since angiotensin II is a pro-inflammatory compound that can induce the production of reactive oxygen species due to activation of the NADPH-dependent oxidase complex, this peptide might contribute to dopaminergic cell death. In this review, three different strategies to interfere with the pathogenesis or the progression of Parkinson's disease are discussed. They include inhibition of the angiotensin-converting enzyme, blockade of the angiotensin II type 1 receptor and stimulation of the angiotensin II type 2 receptor.
引用
收藏
页码:49 / 56
页数:8
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