Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins

被引：0
|
作者：
Brahmbhatt, D. I. [1 ]
Kaneria, Ankit R. [1 ]
Patel, Anil K. [1 ]
Patel, Niraj H. [1 ]
机构：
[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 07期
关键词：
Coumarin; pyridyl coumarin; 3-substituted coumarin; 6-substituted coumarin; pyrazolyl chalcone; Krohnke's pyridine synthesis; ALPHA-PYRONOCHALCONES; CYCLIZATION PRODUCTS; DERIVATIVES;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 4a-l and 4-methyl-3-phenyl-6[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 5a-f have been synthesized by reacting 3-coumarinoylmethyl pyridinium bromides 1a,b and 4-methyl-3-phenyl-6-coumarinoylmethyl pyridinium bromide 2 with pyrazolyl chalcones 3a-f respectively under Krohnke's reaction conditions. All the synthesized compounds 4a-l and 5a-f have been screened for their antibacterial activity against Escherichia coli (Gram -ve bacteria), Bacillus subtillis (Gram +ve bacteria) and antifungal activity against Candida albican (Fungi).
引用
收藏
页码：971 / 977
页数：7
相关论文
共 50 条
  • [31] 4-{3,5-Bis[2,3,5,6-tetrafluoro-4-(piperazin-1-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl}benzaldehyde in the Synthesis of New Dendritic Chromophores
    Ishchenko, R. A.
    Orlova, N. A.
    Shelkovnikov, V. V.
    Maksimov, A. M.
    Ryazanov, N. D.
    Berezhnaya, V. N.
    Chernonosov, A. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2025, 61 (01) : 184 - 189
  • [32] Crystal structure of 3-(6-(5-amino-1-phenyl-1H-pyrazol-3-yl)pyridin-2-yl)-1-phenyl-1H-pyrazol-5-amine-dioxan (2/1), C25H23N7O
    Amr, Abd El-Galil E.
    Al-Omar, Mohamed A.
    Khalifa, Nagy M.
    Ghabbour, Hazem A.
    Ali, Korany K.
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2016, 231 (02): : 597 - 599
  • [33] Synthesis and Antimicrobial Screening of Some Novel 2-(5-(4-(1H-Benzo[d][1,2,3] triazol-1-yl)phenyl)-4,5-dihydro-1H-pyrazol3-yl) phenols Incorporated by Triazole Moiety
    Shaikh, Mohammad U.
    Jadhav, Ganesh R.
    Kale, Rajesh P.
    Chate, Asha V.
    Nagargoje, Deepak R.
    Gill, Charansingh H.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 51 (02) : 513 - 517
  • [34] Facile synthesis of 4-((5-substituted-1H-indol-3-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ols by selective reduction
    Reddy, Gaddam Ganga
    Reddy, Chittireddy Venkata Ramana
    Dubey, Pramod Kumar
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2019, 58 (09): : 1042 - 1048
  • [35] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 4-(COUMARIN-3-YL)/ARYL-2-(3,5-DIMETHYLPYRAZOL-1-YL) THIAZOLES
    Aggarwal, Ranjana
    Kumar, Sunil
    Sharma, Chetan
    Aneja, Kamal R.
    Singh, Shiv R.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 21 (04) : 331 - 336
  • [36] Synthesis and Structural Characterization of Isostructural 4-(4-Aryl)-2-(5-(4-fluorophenyl)-3-(1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles
    Kariuki, Benson M.
    Abdel-Wahab, Bakr F.
    El-Hiti, Gamal A.
    CRYSTALS, 2021, 11 (07)
  • [37] Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
    Whitt, Jedidiah
    Duke, Cameron
    Ali, Mohamad Akbar
    Chambers, Steven A.
    Khan, Md Mahbub Kabir
    Gilmore, David
    Alam, Mohammad A.
    ACS OMEGA, 2019, 4 (10): : 14284 - 14293
  • [38] Synthesis and Antimicrobial Activity of Bis[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)phenyl]methanes and Bis[(triazolo[3,4-b]thiadiazepin-3-yl)phenyl]methanes
    Srinivas, Avula
    ACTA CHIMICA SLOVENICA, 2016, 63 (01) : 173 - 179
  • [39] 3-Hydroxy-1-methyl-2-[4-(piperidin-1-yl)phenyl]quinolin-4(1H)-one
    Wera, Michal
    Pivovarenko, Vasyl G.
    Sikorski, Artur
    Lis, Tadeusz
    Blazejowski, Jerzy
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O654 - U2051
  • [40] 4-{4-[(4-Oxoquinazolin-3-yl)methyl]-1H-1,2,3-triazol-1-yl}butyl acetate
    Ouahrouch, Abdelaaziz
    Taourirte, Moha
    Lazrek, Hassan B.
    El Azhari, Mohamed
    Saadi, Mohamed
    El Ammari, Lahcen
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O3191 - U1238
12345