Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins

被引：0

作者：

Brahmbhatt, D. I. ^{[1
]}

Kaneria, Ankit R. ^{[1
]}

Patel, Anil K. ^{[1
]}

Patel, Niraj H. ^{[1
]}

机构：

[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 07期

关键词：

Coumarin; pyridyl coumarin; 3-substituted coumarin; 6-substituted coumarin; pyrazolyl chalcone; Krohnke's pyridine synthesis; ALPHA-PYRONOCHALCONES; CYCLIZATION PRODUCTS; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 4a-l and 4-methyl-3-phenyl-6[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 5a-f have been synthesized by reacting 3-coumarinoylmethyl pyridinium bromides 1a,b and 4-methyl-3-phenyl-6-coumarinoylmethyl pyridinium bromide 2 with pyrazolyl chalcones 3a-f respectively under Krohnke's reaction conditions. All the synthesized compounds 4a-l and 5a-f have been screened for their antibacterial activity against Escherichia coli (Gram -ve bacteria), Bacillus subtillis (Gram +ve bacteria) and antifungal activity against Candida albican (Fungi).

引用

页码：971 / 977

页数：7

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