Salinomycin - A New Cancer Drug Candidate

被引：90
作者：
Huczynski, Adam [1 ]
机构：
[1] Adam Mickiewicz Univ, Fac Chem, Dept Biochem, PL-60780 Poznan, Poland
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 79卷 / 03期
关键词：
drug design; drug discovery; natural product; therapeutic target; SODIUM COMPLEX; STEM-CELL; APOPTOSIS; IONOPHORE; TOXICITY; P21; NMR;
D O I：
10.1111/j.1747-0285.2011.01287.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resistant cancer cells may define salinomycin as a novel anticancer drug.
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收藏
页码：235 / 238
页数：4
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