Salinomycin - A New Cancer Drug Candidate

被引：88
作者：
Huczynski, Adam [1 ]
机构：
[1] Adam Mickiewicz Univ, Fac Chem, Dept Biochem, PL-60780 Poznan, Poland
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 79卷 / 03期
关键词：
drug design; drug discovery; natural product; therapeutic target; SODIUM COMPLEX; STEM-CELL; APOPTOSIS; IONOPHORE; TOXICITY; P21; NMR;
D O I：
10.1111/j.1747-0285.2011.01287.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resistant cancer cells may define salinomycin as a novel anticancer drug.
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收藏
页码：235 / 238
页数：4
相关论文
共 27 条
  • [1] Salinomycin induces calpain and cytochrome c-mediated neuronal cell death
    Boehmerle, W.
    Endres, M.
    [J]. CELL DEATH & DISEASE, 2011, 2 : e168 - e168
  • [2] DANFORTH HD, 1977, POULTRY SCI, V56, P926, DOI 10.3382/ps.0560926
  • [3] Salinomycin Selectively Targets 'CD133+' Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines
    Dong, Tao-Tao
    Zhou, Hou-Min
    Wang, Lin-Lin
    Feng, Bo
    Lv, Bo
    Zheng, Min-Hua
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2011, 18 (06) : 1797 - 1804
  • [4] POLYETHER IONOPHORES
    DUTTON, CJ
    BANKS, BJ
    COOPER, CB
    [J]. NATURAL PRODUCT REPORTS, 1995, 12 (02) : 165 - 181
  • [5] Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells
    Fuchs, Dominik
    Daniel, Volker
    Sadeghi, Mahmoud
    Opelz, Gerhard
    Naujokat, Cord
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 394 (04) : 1098 - 1104
  • [6] Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells
    Fuchs, Dominik
    Heinold, Andreas
    Opelz, Gerhard
    Daniel, Volker
    Naujokat, Cord
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 390 (03) : 743 - 749
  • [7] Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
    Gupta, Piyush B.
    Onder, Tamer T.
    Jiang, Guozhi
    Tao, Kai
    Kuperwasser, Charlotte
    Weinberg, Robert A.
    Lander, Eric S.
    [J]. CELL, 2009, 138 (04) : 645 - 659
  • [8] A Single Recombinant Adenovirus Expressing p53 and p21-targeting Artificial microRNAs Efficiently Induces Apoptosis in Human Cancer Cells
    Idogawa, Masashi
    Sasaki, Yasushi
    Suzuki, Hiromu
    Mita, Hiroaki
    Imai, Kohzoh
    Shinomura, Yasuhisa
    Tokino, Takashi
    [J]. CLINICAL CANCER RESEARCH, 2009, 15 (11) : 3725 - 3732
  • [9] Kart A, 2008, J ANIM VET ADV, V7, P748
  • [10] Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites
    Kevin, Dion A., II
    Meujo, Damaris A. F.
    Hamann, Mark T.
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2009, 4 (02) : 109 - 146
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