Influence of cardiopulmonary bypass on cognitive functions in patients with ischemic heart disease

被引：0

作者：

Buziashvili, YI ^{[1
]}

Ambatiello, SG ^{[1
]}

Alexakhina, YA ^{[1
]}

Pashchenkov, MV ^{[1
]}

机构：

[1] Bakulayev Sci Ctr Cardiovasc Surg, Moscow, Russia

来源：

ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2005年 / 105卷 / 01期

关键词：

ischemic heart disease; cardiopulmonary bypass; cognitive functions;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Forty patients with ischemic heart disease subjected to coronary artery bypass graft surgery (CARGS) have been studied in conditions of cardiopulmonary bypass. All the patients underwent neuropsychological testing and enzyme immunoassay of chemokines (IL-8, IP-10, MCP-1, MCP-3, MIP-1 beta, SDF-1 alpha) and cytokines (TNF-alpha and IL-10). The study aimed at evaluation of the presence and severity of cognitive deficit developing after the surgery in conditions of cardiopulmonary bypass as well as of intrasurgery effect of tracilol on its expression. On day 9 after CARGS, there was an impairment of attention, audio-speech and memory and dynamic praxis. Tracilol exerted a pronounced neuroprotective action by inhibiting systemic inflammation response. Patients on intrasurgery treatment with tracilol did not demonstrate clinically significant cognitive deficit in the early postoperative period.

引用

页码：30 / 35

页数：6

共 17 条

[11]

Krishnadasan B, 2000, J CARDIOTHOR VASC AN, V14, P6

[12] IL-17 and IFN-γ mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat [J].