Immune defence against EBV and EBV-associated disease

被引：73
作者：
Long, Heather M. [1 ]
Taylor, Graham S. [1 ]
Rickinson, Alan B. [1 ]
机构：
[1] Univ Birmingham, Sch Canc Sci, Birmingham B15 2TT, W Midlands, England
来源：
CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 02期
基金：
英国医学研究理事会;
关键词：
EPSTEIN-BARR-VIRUS; T-CELL RESPONSES; HLA-CLASS-I; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; TRANSFORMED B-CELLS; INFECTIOUS-MONONUCLEOSIS; NASOPHARYNGEAL CARCINOMA; HODGKIN LYMPHOMA; NATURAL-KILLER; CORD BLOOD;
D O I：
10.1016/j.coi.2010.12.014
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Epstein-Barr virus (EBV), a B-lymphotropic herpesvirus widespread in the human population and normally contained as an asymptomatic infection by T cell surveillance, nevertheless causes infectious mononucleosis and is strongly linked to several types of human cancer. Here we describe new findings on the range of cellular immune responses induced by EBV infection, on viral strategies to evade those responses and on the links between HLA gene loci and EBV-induced disease. The success of adoptive T cell therapy for EBV-driven post-transplant lymphoproliferative disease is stimulating efforts to target other EBV-associated tumours by immunotherapeutic means, and has reawakened interest in the ultimate intervention strategy, a prophylactic EBV vaccine.
引用
收藏
页码：258 / 264
页数：7
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