Imperative role of electron microscopy in toxicity assessment: A review

被引：6

作者：

Grover, Aseem ^{[1
]}

Sinha, Reshma ^{[1
]}

Jyoti, Divya ^{[1
]}

Faggio, Caterina ^{[2
]}

机构：

[1] Shoolini Univ Biotechnol & Management Sci, Sch Biol & Environm Sci, Bajhol, India

[2] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy

来源：

MICROSCOPY RESEARCH AND TECHNIQUE | 2022年 / 85卷 / 05期

关键词：

SARS CoV2; scanning electron microscopy; toxicity; transmission electron microscopy; ultrastructure; CYPRINUS-CARPIO; CRYOELECTRON MICROSCOPY; ULTRASTRUCTURAL-CHANGES; SILVER NANOPARTICLES; GOLD NANOPARTICLES; WASTE-WATER; FISH SCALES; GILLS; TRANSMISSION; EXPOSURE;

D O I：

10.1002/jemt.24029

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Electron microscope (EM) was developed in 1931 and since then microscopical examination of both the biological and non-biological samples has been revolutionized. Modifications in electron microscopy techniques, such as scanning EM and transmission EM, have widened their applicability in the various sectors such as understanding of drug toxicity, development of mechanism, criminal site investigation, and characterization of the nano-molecule. The present review summarizes its role in important aspects such as toxicity assessment and disease diagnosis in special reference to SARS-COV2. In the biological system, EM studies have elucidated the impact of toxicants at the ultra-structural level in various tissue in conformity to physiological alterations. Thus, EM can be concluded as an important tool in toxicity assessment and disease prognosis.

引用

页码：1976 / 1989

页数：14

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