Superparamagnetic Iron Oxide Nanoparticle Micelles Stabilized by Recombinant Oleosin for Targeted Magnetic Resonance Imaging

被引：28
|
作者：
Vargo, Kevin B. [1 ]
Al Zaki, Ajlan [2 ]
Warden-Rothman, Robert [2 ]
Tsourkas, Andrew [2 ]
Hammer, Daniel A. [1 ,2 ]
机构：
[1] Univ Penn, Dept Chem & Biomol Engn, Philadelphia, PA 19103 USA
[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19103 USA
来源：
SMALL | 2015年 / 11卷 / 12期
基金：
美国国家科学基金会;
关键词：
PROTEIN SECONDARY STRUCTURE; CIRCULAR-DICHROISM SPECTRA; ARTIFICIAL OIL BODIES; IN-VITRO; SURFACE; SIZE; CELLS; INTERNALIZATION; ADSORPTION; PARTICLES;
D O I：
10.1002/smll.201402017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1409 / 1413
页数：5
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