Tissue-specific differences in mitochondrial activity and biogenesis

被引：131

作者：

Fernandez-Vizarra, Erika ^{[1
]}

Enriquez, Jose A. ^{[1
,2
]}

Perez-Martos, Acisclo ^{[1
]}

Montoya, Julio ^{[1
]}

Fernandez-Silva, Patricio ^{[1
]}

机构：

[1] Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, E-50009 Zaragoza, Spain

[2] Ctr Nacl Invest Cardiovasc Carlos III, Madrid 28029, Spain

来源：

MITOCHONDRION | 2011年 / 11卷 / 01期

关键词：

OXPHOS capacity; mtDNA; Tissue-specificity; Copy number; CYTOCHROME-C-OXIDASE; DNA COPY NUMBER; IN-VIVO CONTROL; GENE-EXPRESSION; HUMAN-CELLS; OXIDATIVE-PHOSPHORYLATION; RESPIRATORY-CHAIN; SKELETAL-MUSCLE; RAT-TISSUES; MUTATION;

D O I：

10.1016/j.mito.2010.09.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Each cell type develops and maintains a specific oxidative phosphorylation (OXPHOS) capacity to satisfy its metabolic and energetic demands. This implies that there are differences between tissues in mitochondrial number, function, protein composition and morphology. The OXPHOS system biogenesis requires the coordinated expression of both mitochondrial and nuclear genomes. Mitochondrial DNA (mtDNA) expression can be regulated at different levels (replication, transcription, translation and post-translational levels) to contribute to the final observed OXPHOS activities. By analyzing five mammalian tissues, we evaluated the differences in the cellular amount of mtDNA and its correlation with the final observed mitochondrial activity. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：207 / 213

页数：7

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