Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases

被引：50

作者：

Faulds, Malin Hedengran ^{[1
]}

Zhao, Chunyan ^{[1
]}

Dahlman-Wright, Karin ^{[1
]}

机构：

[1] Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden

来源：

CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 06期

关键词：

ELEMENT-BINDING PROTEIN-1C; BILE-ACID BIOSYNTHESIS; CHOLESTEROL-METABOLISM; OXYSTEROL RECEPTORS; LIPOPROTEIN-LIPASE; LIPID-METABOLISM; GENE-EXPRESSION; MICE LACKING; PPAR-GAMMA; IN-VIVO;

D O I：

10.1016/j.coph.2010.07.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolic syndrome constitutes a group of metabolic conditions that increase the risk of developing diseases, including cardiovascular disease (CVD) and type 2 diabetes (120) LXR alpha/beta are regulators of lipogenesis, cholesterol/glucose homoeostasis and inflammatory pathways, processes that are intertwined with development of the metabolic syndrome The employment of LXRs as pharmaceutical targets for treatment of various aspects of the metabolic syndrome has been promptly investigated but serious side effects like hepatic steatosis have hampered this process Novel treatment regimes now focus on development of isoform-specific or tissue-specific LXR agonist/antagonist compounds to circumvent effects on lipid biosynthesis Other strategies to explore the beneficial aspects of LXR activation include targeting co-factors or pathways that are modifying LXR activity

引用

页码：692 / 697

页数：6

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