Global White Matter Abnormalities in Schizophrenia: A Multisite Diffusion Tensor Imaging Study

被引：95

作者：

White, Tonya ^{[1
,2
,3
]}

Magnotta, Vincent A. ^{[4
]}

Bockholt, H. Jeremy ^{[5
]}

Williams, Sumner ^{[5
]}

Wallace, Stuart ^{[6
]}

Ehrlich, Stefan ^{[6
,7
]}

Mueller, Bryon A. ^{[1
]}

Ho, Beng-Choon ^{[8
]}

Jung, Rex E. ^{[9
]}

Clark, Vincent P. ^{[9
]}

Lauriello, John ^{[12
]}

Bustillo, Juan R. ^{[10
]}

Schulz, S. Charles

Gollub, Randy L. ^{[6
,7
]}

Andreasen, Nancy C. ^{[8
]}

Calhoun, Vince D. ^{[5
,11
]}

Lim, Kelvin O. ^{[1
,2
,13
]}

机构：

[1] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55454 USA

[2] Ctr Magnet Resonance Res, Minneapolis, MN 55454 USA

[3] Erasmus Univ, Dept Child & Adolescent Psychiat, NL-3000 CB Rotterdam, Netherlands

[4] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA

[5] Mind Res Network, Albuquerque, NM 87106 USA

[6] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02129 USA

[7] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02129 USA

[8] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA

[9] Univ New Mexico, Dept Psychol, Albuquerque, NM 87106 USA

[10] Univ New Mexico, Dept Psychiat, Albuquerque, NM 87106 USA

[11] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87106 USA

[12] Univ Missouri, Dept Psychiat, Columbia, MO 65212 USA

[13] Minneapolis Vet Adm Med Ctr, Minneapolis, MN 55417 USA

来源：

SCHIZOPHRENIA BULLETIN | 2011年 / 37卷 / 01期

基金：

美国国家卫生研究院;

关键词：

first-episode schizophrenia; fractional anisotropy; neuroimaging; DTI; microstructure; CHILDHOOD-ONSET SCHIZOPHRENIA; PROGRESSIVE BRAIN CHANGES; DYSFUNCTION; ADOLESCENCE; EPISODE; DENSITY; CORTEX; MRI;

D O I：

10.1093/schbul/sbp088

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Emerging evidence implicates white matter (WM) abnormalities in the pathophysiology of schizophrenia. However, there is considerable heterogeneity in the presentation of WM abnormalities in the existing studies. The object of this study was to evaluate WM integrity in a large sample of patients with first-episode (FE) and chronic schizophrenia in comparison to matched control groups. Our goal was to assess whether WM findings occurred early in the illness or whether these abnormalities developed with the illness over time. Methods: Participants included 114 patients with schizophrenia (31 FE and 83 chronic patients) and 138 matched controls. High-resolution structural and diffusion tensor images were obtained on all participants. Measures of fractional anisotropy (FA) were calculated for the 4 cortical lobes and the cerebellum and brain stem. Results: FA was significant lower in patients vs controls in the whole brain and individually in the frontal, parietal, occipital, and temporal lobes. FA was not significantly different in the brain stem or cerebellum. FA differences were significant only in patients with chronic schizophrenia and not in the FE group. Conclusions: We found global differences in the WM microstructure in patients with chronic but not FE schizophrenia. These findings suggest progressive alterations in WM microstructure.

引用

页码：222 / 232

页数：11

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