Discovery and optimization of a novel series of thrombin receptor (PAR-1) antagonists: Potent, selective peptide mimetics based on indole and indazole templates

被引：75
|
作者：
Zhang, HC [1 ]
Derian, CK
Andrade-Gordon, P
Hoekstra, WJ
McComsey, DF
White, KB
Poulter, BL
Addo, MF
Cheung, WM
Damiano, BP
Oksenberg, D
Reynolds, EE
Pandey, A
Scarborough, RM
Maryanoff, BE
机构：
[1] RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA
[2] COR Therapeut Inc, S San Francisco, CA 94080 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 07期
关键词：
D O I：
10.1021/jm000506s
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：1021 / 1024
页数：4
相关论文
共 50 条
  • [1] Discovery and optimization of a novel class of thrombin receptor (PAR-1) antagonists: Potent, selective peptide-mimetics based on indole and indazole templates.
    Maryanoff, BE
    Zhang, HC
    Andrade-Gordon, P
    Derian, CK
    McComsey, DF
    Hoekstra, WJ
    White, KB
    Poulter, BL
    Addo, MF
    Cheung, WM
    Damiano, BP
    Oksenberg, D
    Reynolds, EE
    Scarborough, RM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U59 - U60
  • [2] Novel indole-based peptidomimetics as potent thrombin receptor (PAR-1) antagonists.
    Zhang, HC
    Hoekstra, WJ
    Maryanoff, BE
    McComsey, DF
    Poulter, BL
    White, KB
    Addo, MF
    Andrade-Gordon, P
    Derian, CK
    Oksenberg, D
    Reynolds, EE
    Scarborough, RM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 218 : U910 - U910
  • [3] Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists
    Clasby, MC
    Chackalamannil, S
    Czarniecki, M
    Doller, D
    Eagen, K
    Greenlee, WJ
    Lin, Y
    Tsai, H
    Xia, Y
    Ahn, HS
    Agans-Fantuzzi, J
    Boykow, G
    Chintala, M
    Foster, C
    Bryant, M
    Lau, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (06) : 1544 - 1548
  • [4] Discovery and optimization of potent orally active small molecular thrombin receptor PAR-1 antagonists.
    Kawahara, T
    Suzuki, S
    Kogushi, M
    Matsuoka, T
    Kobayashi, H
    Kajiwara, A
    Hishinuma, I
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U215 - U215
  • [5] Discovery and optimization of potent orally active small molecular thrombin receptor(PAR-1) antagonists.
    Kawahara, T
    Suzuki, S
    Matsuura, F
    Clark, RSJ
    Kogushi, M
    Kobayashi, H
    Hishinuma, L
    Sato, N
    Terauchi, T
    Kajiwara, A
    Matsuoka, T
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U21 - U21
  • [6] Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide
    Zhang, HC
    McComsey, DF
    White, KB
    Addo, MF
    Andrade-Gordon, P
    Derian, CK
    Oksenberg, D
    Maryanoff, BE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (16) : 2105 - 2109
  • [7] Thrombin receptor (PAR-1) antagonists as novel antithrombotic agents
    Chackalamannil, S
    Xia, Y
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (04) : 493 - 505
  • [8] Design and synthesis of novel himbacine based thrombin receptor (Par-1) antagonists
    Chelliah, Mariappan V.
    Chackalamannil, Samuel
    Xia, Yan
    Eagen, Keith
    Tsai, Hsingan
    Clasby, Martin
    Gao, Xiaobang
    Greenlee, William J.
    Ahn, Ho-Sam
    Boykow, George
    Foster, Carolyn
    Hsieh, Yunsheng
    Agans-Fantuzzi, Jacqueline
    Bryant, Matthew
    Chintala, Madhu
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [9] A novel series of indazole-/indole-based glucagon receptor antagonists
    Lin, Songnian
    Zhang, Fengqi
    Jiang, Guoqiang
    Qureshi, Sajjad A.
    Yang, Xiaodong
    Chicchi, Gary G.
    Tota, Laurie
    Bansal, Alka
    Brady, Edward
    Trujillo, Maria
    Salituro, Gino
    Miller, Corey
    Tata, James R.
    Zhang, Bei B.
    Parmee, Emma R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (19) : 4143 - 4147
  • [10] Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists
    Barrow, JC
    Nantermet, PG
    Selnick, HG
    Glass, KL
    Ngo, PL
    Young, MB
    Pellicore, JM
    Breslin, MJ
    Hutchinson, JH
    Freidinger, RM
    Condra, C
    Karczewski, J
    Bednar, RA
    Gaul, SL
    Stern, A
    Gould, R
    Connolly, TM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (20) : 2691 - 2696
12345