The frequency of high-grade intraepithelial neoplasia in anal/perianal warts is higher than previously recognized

被引：33
作者：
McCloskey, J. C.
Metcalf, C.
French, M. A.
Flexman, J. P.
Burke, V.
Beilin, L. J.
机构：
[1] Royal Perth Hosp, Sexual Hlth Serv, Perth, WA 6847, Australia
[2] Royal Perth Hosp, Dept Anat Pathol, Perth, WA 6847, Australia
[3] Univ Western Australia, Royal Perth Hosp, Dept Clin Immunol, Nedlands, WA 6009, Australia
[4] Univ Western Australia, Sch Surg & Pathol, Nedlands, WA 6009, Australia
[5] Royal Perth Hosp, Dept Microbiol, Perth, WA 6847, Australia
[6] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia
来源：
INTERNATIONAL JOURNAL OF STD & AIDS | 2007年 / 18卷 / 08期
关键词：
genital warts; perianal intraepithelial neoplasia; anal intraepitheliall neoplasia; treatment; human immunodeficiency virus;
D O I：
10.1258/095646207781439694
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A retrospective review of the prevalence of intraepithelial neoplasia (IN) in surgically removed perianal/anal warts from December 1995 to December 2004 was undertaken in patients referred to the Sexual Health Clinic at Royal Perth Hospital. Data were analysed from 115 men and 38 women, 29 of whom had HIV infection (27 men and two women). Perianal/ anal IN within the warts was found in 78% (52% high grade) of men with HIV infection. In men without HIV infection, the overall rate of IN within warts was 33% (20% high grade). The IN rate was 8.3% for HIV-negative women (2.8% high grade). Rates of IN within perianal/anal warts in men with or without HIV infection are higher than previously reported, and suggest the likelihood of a substantial increase in the future incidence of anal cancer. The association between IN and genital warts needs to be further studied.
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页码：538 / 542
页数：5
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