Synthesis and biological property of some novel 1,3,4-oxadiazoles

被引：45

作者：

Ramaprasad, G. C. ^{[1
,2
]}

Kalluraya, Balakrishna ^{[1
]}

Kumar, B. Sunil ^{[3
]}

Hunnur, Ravindra K. ^{[3
]}

机构：

[1] Mangalore Univ, Dept Studies Chem, Mangalagangothri 574199, Karnataka, India

[2] Syngene Int Ltd, Bangalore 99, Karnataka, India

[3] NET Pharm Coll, Dept Pharmaceut Sci, Raichur 584103, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 10期

关键词：

1,3,4-Oxadiazole; Suzuki coupling; Boronic acids; Antimicrobial and analgesic activity; ANTIINFLAMMATORY ACTIVITY; HETEROCYCLIC-COMPOUNDS; DERIVATIVES; AGENTS; DESIGN; BASES; ACID;

D O I：

10.1016/j.ejmech.2010.07.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1'-biphenyl)-3-yl]-1,3,4-oxadiazole-2 (3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by (1)H NMR, (13)C NMR, (19)F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity. (C) 2010 Elsevier Masson SAS. All rights reserved

引用

页码：4587 / 4593

页数：7

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