Advancing Research on the Complex Interrelations Between Atrial Fibrillation and Heart Failure A Report From a US National Heart, Lung, and Blood Institute Virtual Workshop

被引：45

作者：

Al-Khatib, Sana M. ^{[1
,2
]}

Benjamin, Emelia J. ^{[3
,4
]}

Albert, Christine M. ^{[5
]}

Alonso, Alvaro ^{[6
]}

Chauhan, Cynthia ^{[7
]}

Chen, Peng-Sheng ^{[8
,9
]}

Curtis, Anne B. ^{[10
]}

Desvigne-Nickens, Patrice ^{[11
]}

Ho, Jennifer E. ^{[12
,13
]}

Lam, Carolyn S. P. ^{[11
,14
,15
]}

Link, Mark S. ^{[16
]}

Patton, Kristen K. ^{[17
]}

Redfield, Margaret M. ^{[18
]}

Rienstra, Michiel ^{[19
]}

Rosenberg, Yves ^{[11
]}

Schnabel, Renate ^{[20
]}

Spertus, John A. ^{[21
]}

Stevenson, Lynne Warner ^{[22
]}

Hills, Mellanie True ^{[23
]}

Voors, Adriaan A. ^{[19
]}

Cooper, Lawton S. ^{[22
]}

Go, Alan S. ^{[24
,25
,26
,27
,28
]}

机构：

[1] Duke Univ, Div Cardiol, Med Ctr, Durham, NC USA

[2] Duke Univ, Duke Clin Res Inst, Med Ctr, Durham, NC USA

[3] Boston Univ, Sch Med, Dept Med, Cardiovasc Med, Boston, MA 02118 USA

[4] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA

[5] Cedars Sinai Med Ctr, Dept Cardiol, Smidt Heart Inst, Los Angeles, CA 90048 USA

[6] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[7] Patient Representat, Wichita, KS USA

[8] Indiana Univ Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA

[9] Indiana Univ Sch Med, Div Cardiol, Dept Med, Indianapolis, IN 46202 USA

[10] Univ Buffalo, Jacobs Sch Med & Biomed Sci, Dept Med, Buffalo, NY USA

[11] NHLBI, Div Cardiovasc Sci, NIH, Bldg 10, Bethesda, MD 20892 USA

[12] Harvard Med Sch, Div Cardiovasc Sci, Massachusetts Gen Hosp, Corrigan Minehan Heart Ctr,Cardiovasc Res Ctr,Dep, Boston, MA 02115 USA

[13] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA

[14] Natl Heart Ctr Singapore, Singapore, Singapore

[15] Duke Natl Univ Singapore, Singapore, Singapore

[16] Univ Texas Southwestern Med Ctr Dallas, Dept Med, Div Cardiol, Dallas, TX 75390 USA

[17] Univ Washington, Div Cardiol, Seattle, WA 98195 USA

[18] Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA

[19] Univ Groningen, Univ Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[20] Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, Hamburg, Germany

[21] Univ Missouri, Cardiovasc Div, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA

[22] Vanderbilt Univ, Med Ctr, Div Cardiol, Nashville, TN USA

[23] StopAfib Amer Fdn Womens Hlth, Decatur, GA USA

[24] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA

[25] Univ Calif San Francisco, Dept Epidemiol Biostat & Med, San Francisco, CA 94143 USA

[26] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[27] Stanford Univ, Dept Hlth Res, Stanford, CA 94305 USA

[28] Stanford Univ, Dept Policy, Stanford, CA 94305 USA

来源：

CIRCULATION | 2020年 / 141卷 / 23期

基金：

美国国家卫生研究院;

关键词：

atrial fibrillation; heart failure; research; PRESERVED EJECTION FRACTION; VAGUS NERVE-STIMULATION; QUALITY-OF-LIFE; NATRIURETIC PEPTIDE; CATHETER ABLATION; DYSFUNCTION; MECHANISMS; PREVENTION; OUTCOMES; RISK;

D O I：

10.1161/CIRCULATIONAHA.119.045204

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The interrelationships between atrial fibrillation (AF) and heart failure (HF) are complex and poorly understood, yet the number of patients with AF and HF continues to increase worldwide. Thus, there is a need for initiatives that prioritize research on the intersection between AF and HF. This article summarizes the proceedings of a virtual workshop convened by the US National Heart, Lung, and Blood Institute to identify important research opportunities in AF and HF. Key knowledge gaps were reviewed and research priorities were proposed for characterizing the pathophysiological overlap and deleterious interactions between AF and HF; preventing HF in people with AF; preventing AF in individuals with HF; and addressing symptom burden and health status outcomes in AF and HF. These research priorities will hopefully help inform, encourage, and stimulate innovative, cost-efficient, and transformative studies to enhance the outcomes of patients with AF and HF.

引用

页码：1915 / 1926

页数：12

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