A novel, thioacetal based linker for solid-phase synthesis

被引：32
作者：
Huwe, CM [1 ]
Künzer, H [1 ]
机构：
[1] Schering AG, Preclin Drug Res, D-13342 Berlin, Germany
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 04期
关键词：
combinatorial chemistry; solid-phase synthesis; thioacetals;
D O I：
10.1016/S0040-4039(98)02580-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Commercially available (+/-)-alpha-lipoic acid was employed as a novel, chemically robust linker for the immobilization of ketones. The utility of this thioacetal based linker in solid-phase synthesis was demonstrated by synthesizing several 4-acetylbiphenyls and 4-alkoxyacetophenones via Suzuki and Mitsunobu reactions, respectively. The products were easily cleaved from solid support by treatment with [bis(trifluoroacetoxy)iodo] benzene. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：683 / 686
页数：4
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