Meningeal lymphatics, immunity and neuroinflammation

被引:24
作者
Frederick, Natalie [1 ]
Louveau, Antoine [1 ,2 ]
机构
[1] Cleveland Clin, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Mol Med, Cleveland Clin, Coll Med, Cleveland, OH 44106 USA
关键词
SYSTEM; BRAIN; CELLS; FLUID; LYMPHANGIOGENESIS; CLEARANCE; HEALTH; GAMMA;
D O I
10.1016/j.conb.2019.11.010
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the past five years, the surrounding of the brain, that is the meninges (singular meninx) have evolved from being a physical barrier that protects the brain parenchyma to becoming a central player for both the maintenance of normal brain function and the modulation of neurological disorders. Indeed, the meninges are an immunologically active compartment that communicates with the periphery via the (re)discovered meningeal lymphatic system. From its ties to both the periphery and the central nervous system, the meninges are becoming a prevalent organ to understand and modulate brain homeostasis. Here we will focus on current advances in our understanding of the meningeal compartment with an emphasis on the meningeal lymphatic network as a key regulator.
引用
收藏
页码:41 / 47
页数:7
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