A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study

被引：45

作者：

Visco, Carlo ^{[1
]}

Marcheselli, Luigi ^{[2
]}

Mina, Roberto ^{[3
]}

Sassone, Marianna ^{[4
]}

Guidetti, Anna ^{[5
]}

Penna, Domenico ^{[6
]}

Cattaneo, Chiara ^{[7
]}

Bonuomo, Valentina ^{[1
]}

Busca, Alessandro ^{[3
]}

Ferreri, Andres Jose Maria ^{[4
]}

Bruna, Riccardo ^{[8
,9
]}

Petrucci, Luigi ^{[10
]}

Cairoli, Roberto ^{[11
]}

Salvini, Marco ^{[12
,13
]}

Bertu, Lorenza ^{[12
,13
]}

Ladetto, Marco ^{[14
]}

Pilerci, Sofia ^{[15
]}

Pinto, Antonello ^{[16
]}

Ramadan, Safaa ^{[17
]}

Marchesi, Francesco ^{[18
]}

Cavo, Michele ^{[19
]}

Arcaini, Luca ^{[20
,21
]}

Coviello, Elisa ^{[22
]}

Romano, Alessandra ^{[23
]}

Musto, Pellegrino ^{[24
,25
]}

Massaia, Massimo ^{[26
]}

Fracchiolla, Nicola ^{[27
]}

Marchetti, Monia ^{[14
]}

Scattolin, Annamaria ^{[28
]}

Tisi, Maria Chiara ^{[29
]}

Cuneo, Antonio ^{[30
]}

Della Porta, Matteo ^{[31
,32
]}

Trentin, Livio ^{[33
]}

Turrini, Marco ^{[34
]}

Gherlinzoni, Filippo ^{[35
]}

Tafuri, Agostino ^{[36
]}

Galimberti, Sara ^{[37
]}

Bocchia, Monica ^{[38
]}

Cardinali, Valeria ^{[39
]}

Cilloni, Daniela ^{[40
]}

Corso, Alessandro ^{[41
]}

Armiento, Daniele ^{[42
]}

Rigacci, Luigi ^{[43
]}

La Barbera, Elettra Ortu ^{[44
]}

Gambacorti-Passerini, Carlo ^{[45
]}

Visani, Giuseppe ^{[46
]}

Vallisa, Daniele ^{[47
]}

Venditti, Adriano ^{[48
]}

Selleri, Carmine ^{[49
]}

Conconi, Annarita ^{[50
]}

机构：

[1] Univ Verona, Dept Med, Sect Hematol, Verona, Italy

[2] Fdn Italiana Linf Onlus, Modena, Italy

[3] Univ Torino, Azienda Osped Univ Citta Salute & Sci, Div Hematol, Myeloma Unit, Turin, Italy

[4] Ist Ricovero & Cura Carattere Sci IRCCS San Raffa, Lymphoma Unit, Milan, Italy

[5] Univ Milan, Fdn Ist Ricovero & Cura Carattere Sci Ist Nazl Tu, Hematol & Bone Marrow Transplantat, Milan, Italy

[6] Azienda Unita Sanit Locale Ist Ricovero & Cura Ca, Hematol, Reggio Emilia, Italy

[7] Azienda Sociosanit Terr Spedali Civil, Hematol, Brescia, Italy

[8] Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy

[9] Osped Maggiore La Carita, Novara, Italy

[10] Sapienza Univ Rome, Dept Translat & Precis Med, Hematol, Rome, Italy

[11] Azienda Sociosanit Terr Grande Osped Metropolitan, Hematol, Milan, Italy

[12] Univ Insubria, Dept Med & Surg, Varese, Italy

[13] Osped Circolo Varese, Azienda Sociosanit Terr Sette Laghi, Varese, Italy

[14] Azienda Osped Santissimi Antonio & Biagio & Cesar, Hematol, Alessandria, Italy

[15] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[16] Ist Nazl Tumori, Hematol, Ist Ricovero & Cura Carattere Sci, Fdn G Pascale, Naples, Italy

[17] European Inst Oncol, Div Oncohematol, Ist Ricovero & Cura Carattere Sci, Milan, Italy

[18] Ist Ricovero & Cura Carattere Sci Regina Elena Na, Hematol & Stem Cell Transplant Unit, Rome, Italy

[19] Bologna Univ, Seragnoli Inst Hematol, Dept Expt Diagnost & Specialty Med, Sch Med, Bologna, Italy

[20] Fdn Ist Ricovero & Cura Carattere Sci Policlin Sa, Div Hematol, Pavia, Italy

[21] Univ Pavia, Dept Mol Med, Pavia, Italy

[22] Ist Ricovero & Cura Carattere Sci Osped Policlin, Hematol & Bone Marrow Transplant, Genoa, Italy

[23] Univ Catania, Dipartimento Chirurg & Specialita Med Chirurg, Hematol, Catania, Italy

[24] Aldo Moro Univ, Sch Med, Dept Emergency & Organ Transplantat, Bari, Italy

[25] Azienda Osped Univ Consorziale Policlin, Unit Hematol & Stem Cell Transplantat, Bari, Italy

[26] Santa Croce Hosp, Hematol, Cuneo, Italy

[27] Univ Milan, Fdn Ist Ricovero & Cura Carattere Sci Ca Granda O, Oncoematol, Milan, Italy

[28] Osped Angelo Mestre, Hematol, Venice, Italy

[29] Osped San Bortolo, Hematol, Vicenza, Italy

[30] Azienda Osped Univ St Anna, Hematol, Ferrara, Italy

[31] Humanitas Clin & Res Hosp Ist Ricovero & Cura Car, Milan, Italy

[32] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[33] Univ Padua, Dept Med, Hematol & Clin Immunol Unit, Padua, Italy

[34] Osped Valduce, Hematol, Como, Italy

[35] Osped Ca Foncello, Hematol, Treviso, Italy

[36] Sapienza, Univ Hosp St Andrea, Hematol, Rome, Italy

[37] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[38] Univ Siena, Azienda Osped Univ Senese, Hematol Unit, Siena, Italy

[39] Univ Perugia, Hematol Inst, Perugia, Italy

[40] Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, Turin, Italy

[41] Osped Legnano, Hematol, Milan, Italy

[42] Univ Campus Biomed, Stem Cell Transplantat, Unit Hematol, Rome, Italy

[43] Camillo Forlanini Hosp, Hematol, Rome, Italy

[44] Osped Santa Maria Goretti, Unita Operat Complessa Ematol Trapianto, Latina, Italy

[45] Univ Milano Bicocca, Dept Hematol, Milan, Italy

[46] Azienda Osped Osped Riuniti Marche Nord, Dipartimento OncoEmatol, Pesaro, Italy

[47] Osped Piacenza, Hematol, Piacenza, Italy

[48] Univ Tor Vergata Rome, Dept Biomed & Prevent, Rome, Italy

[49] Univ Salerno, Dept Med, Osped San Giovanni di Dio & Ruggi dAragona, Hematol, Salerno, Italy

[50] Osped Inferm Biella, Hematol, Biella, Italy

来源：

BLOOD ADVANCES | 2022年 / 6卷 / 01期

关键词：

NEW-YORK-CITY; OUTCOMES;

D O I：

10.1182/bloodadvances.2021005691

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lymphoma represents a heterogeneous hematological malignancy (HM), which is characterized by severe immunosuppression. Patients diagnosed of coronavirus disease 2019 (COVID-19) during the course of HM have been described to have poor outcome, with only few reports specifically addressing lymphoma patients. Here, we investigated the clinical behavior and clinical parameters of a large multicenter cohort of adult patients with different lymphoma subtypes, with the aim of identifying predictors of death. The study included 856 patients, of whom 619 were enrolled prospectively in a 1-year frame and were followed-up for a median of 66 days (range 1-395). Patients were managed as outpatient (not-admitted cohort, n = 388) or required hospitalization (n = 468), and median age was 63 years (range 19-94). Overall, the 30-and 100-days mortality was 13% (95% confi-dence interval (CI), 11% to 15%) and 23% (95% CI, 20% to 27%), respectively. Antilymphoma treatment, including anti-CD20 containing regimens, did not impact survival. Patients with Hodgkin's lymphoma had the more favorable survival, but this was partly related to signifi-cantly younger age. The time interval between lymphoma diagnosis and COVID-19 was inversely related to mortality. Multivariable analysis recognized 4 easy-to-use factors (age, gender, lymphocyte, and platelet count) that were associated with risk of death, both in the admitted and in the not-admitted cohort (HR 3.79 and 8.85 for the intermediate-and high risk group, respectively). Overall, our study shows that patients should not be deprived of the best available treatment of their underlying disease and indicates which patients are at higher risk of death. This study was registered with ClinicalTrials.gov, NCT04352556.

引用

页码：327 / 338

页数：12

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