Association of PTPN22 polymorphsims and ankylosing spondylitis susceptibility

被引：0

作者：

Meng, Qingxi ^{[1
]}

Zhang, Xiaojun ^{[1
]}

Liu, Xin ^{[1
]}

Wang, Weiguo ^{[1
]}

Yu, Peng ^{[2
]}

Shan, Qunqun ^{[1
]}

Mao, Zhaohu ^{[1
]}

Zhao, Tingbao ^{[1
]}

机构：

[1] Jinan Mil Area Command, Gen Hosp, Inst Orthoped & Traumatol Chinese PLA, Dept Spinal Cord Injury, Jinan 250031, Shandong, Peoples R China

[2] Jinan Mil Reg, Veteran Inst 1, Jinan, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 01期

关键词：

PTPN22; polymorphism; AS; susceptibility; SINGLE-NUCLEOTIDE POLYMORPHISM; CTLA-4 GENETIC POLYMORPHISMS; RHEUMATOID-ARTHRITIS; FUNCTIONAL POLYMORPHISM; POPULATION; HLA-B27; PROMOTER; DISEASE; CHINESE; VARIANT;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: As a susceptibility gene for AS, the polymorphsims of PTPN22 associated with disease susceptibility. Methods: We selected two SNPs of rs1217406 and rs1217414 within PTPN22 with Haploview software and investigated the relationship between the SNPs of PTPN22 gene and AS susceptibility. 120 AS patients and 100 healthy people were enrolled from Qilu Hospital of Shandong University. And we genotyped the SNPs of PTPN22 with PCR-RFLP method. Results: The results showed that C allele (rs1217406) and T allele (rs1217414) both were risk factors for AS (OR: 3.12, 2.13). The persons with A-T, C-C or C-T haplotypes were more likely to suffer AS (OR: 3.17, 3.66, 4.011). Conclusions: Due to the close relationship of PTPN22 and AS, the study may be helpful for the early diagnosis and differential diagnosis.

引用

页码：933 / 937

页数：5

共 28 条

[11] Whole-genome screening in ankylosing spondylitis: Evidence of non-MHC genetic-susceptibility loci [J].

Laval, SH ;

Timms, A ;

Edwards, S ;

Bradbury, L ;

Brophy, S ;

Milicic, A ;

Rubin, L ;

Siminovitch, KA ;

Weeks, DE ;

Calin, A ;

Wordsworth, BP ;

Brown, MA .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (04) :918-926

[12] The PTPN22 C1858T functional polymorphism and autoimmune diseases - a meta-analysis [J].

Lee, Y. H. ;

Rho, Y. H. ;

Choi, S. J. ;

Ji, J. D. ;

Song, G. G. ;

Nath, S. K. ;

Harley, J. B. .

RHEUMATOLOGY, 2007, 46 (01) :49-56

[13] Potential role of PTPN22 in ankylosing spondylitis, comment on: associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis [J].

Liu, Shan-Shan ;

Ding, Ye ;

Lou, Ji-Quan .

RHEUMATOLOGY INTERNATIONAL, 2014, 34 (10) :1417-1418

[14]

Lv CY, 2011, CLIN INVEST MED, V34, pE370

[15] Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis [J].

Mahmoudi, M. ;

Amirzargar, A. A. ;

Jamshidi, A. R. ;

Farhadi, E. ;

Noori, S. ;

Avraee, M. ;

Nazari, B. ;

Nicknam, M. H. .

EUROPEAN CYTOKINE NETWORK, 2011, 22 (04) :175-180

[16] PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes [J].

Namjou, Bahram ;

Kim-Howard, Xana ;

Sun, Celi ;

Adler, Adam ;

Chung, Sharon A. ;

Kaufman, Kenneth M. ;

Kelly, Jennifer A. ;

Glenn, Stuart B. ;

Guthridge, Joel M. ;

Scofield, Robert H. ;

Kimberly, Robert P. ;

Brown, Elizabeth E. ;

Alarcon, Graciela S. ;

Edberg, Jeffrey C. ;

Kim, Jae-Hoon ;

Choi, Jiyoung ;

Ramsey-Goldman, Rosalind ;

Petri, Michelle A. ;

Reveille, John D. ;

Vila, Luis M. ;

Boackle, Susan A. ;

Freedman, Barry I. ;

Tsao, Betty P. ;

Langefeld, Carl D. ;

Vyse, Timothy J. ;

Jacob, Chaim O. ;

Pons-Estel, Bernardo ;

Niewold, Timothy B. ;

Sivils, Kathy L. Moser ;

Merrill, Joan T. ;

Anaya, Juan-Manuel ;

Gilkeson, Gary S. ;

Gaffney, Patrick M. ;

Bae, Sang-Cheol ;

Alarcon-Riquelme, Marta E. ;

Harley, John B. ;

Criswell, Lindsey A. ;

James, Judith A. ;

Nath, Swapan K. .

PLOS ONE, 2013, 8 (08)

[17] Lack of association between ankylosing spondylitis and a functional polymorphism of PTPN22 proposed as a general susceptibility marker for autoimmunity [J].

Orozco, G ;

García-Porrúa, C ;

López-Nevot, MA ;

Raya, E ;

González-Gay, MA ;

Martín, J .

ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (05) :687-688

[18]

Palomino-Morales R, 2010, CLIN EXP RHEUMATOL, V28, P695

[19] PLINK: A tool set for whole-genome association and population-based linkage analyses [J].

Purcell, Shaun ;

Neale, Benjamin ;

Todd-Brown, Kathe ;

Thomas, Lori ;

Ferreira, Manuel A. R. ;

Bender, David ;

Maller, Julian ;

Sklar, Pamela ;

de Bakker, Paul I. W. ;

Daly, Mark J. ;

Sham, Pak C. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 81 (03) :559-575

[20] The PTPN22 R263Q Polymorphism Is a Risk Factor for Rheumatoid Arthritis in Caucasian Case-Control Samples [J].

Rodriguez-Rodriguez, Luis ;

Taib, Wan Rohani Wan ;

Topless, Ruth ;

Steer, Sophia ;

Gonzalez-Escribano, Maria F. ;

Balsa, Alejandro ;

Pascual-Salcedo, Dora ;

Gonzalez-Gay, Miguel A. ;

Raya, Enrique ;

Fernandez-Gutierrez, Benjamin ;

Gonzalez-Alvaro, Isidoro ;

Bottini, Nunzio ;

Witte, Torsten ;

Viken, Marte K. ;

Coenen, Marieke J. H. ;

van Riel, Piet L. C. M. ;

Franke, Barbara ;

den Heijer, Martin ;

Radstake, Timothy R. D. J. ;

Wordsworth, Paul ;

Lie, Benedicte A. ;

Merriman, Tony R. ;

Martin, Javier .

ARTHRITIS AND RHEUMATISM, 2011, 63 (02) :365-372

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