Association of PTPN22 polymorphsims and ankylosing spondylitis susceptibility

被引：0
作者：
Meng, Qingxi [1 ]
Zhang, Xiaojun [1 ]
Liu, Xin [1 ]
Wang, Weiguo [1 ]
Yu, Peng [2 ]
Shan, Qunqun [1 ]
Mao, Zhaohu [1 ]
Zhao, Tingbao [1 ]
机构：
[1] Jinan Mil Area Command, Gen Hosp, Inst Orthoped & Traumatol Chinese PLA, Dept Spinal Cord Injury, Jinan 250031, Shandong, Peoples R China
[2] Jinan Mil Reg, Veteran Inst 1, Jinan, Shandong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 01期
关键词：
PTPN22; polymorphism; AS; susceptibility; SINGLE-NUCLEOTIDE POLYMORPHISM; CTLA-4 GENETIC POLYMORPHISMS; RHEUMATOID-ARTHRITIS; FUNCTIONAL POLYMORPHISM; POPULATION; HLA-B27; PROMOTER; DISEASE; CHINESE; VARIANT;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: As a susceptibility gene for AS, the polymorphsims of PTPN22 associated with disease susceptibility. Methods: We selected two SNPs of rs1217406 and rs1217414 within PTPN22 with Haploview software and investigated the relationship between the SNPs of PTPN22 gene and AS susceptibility. 120 AS patients and 100 healthy people were enrolled from Qilu Hospital of Shandong University. And we genotyped the SNPs of PTPN22 with PCR-RFLP method. Results: The results showed that C allele (rs1217406) and T allele (rs1217414) both were risk factors for AS (OR: 3.12, 2.13). The persons with A-T, C-C or C-T haplotypes were more likely to suffer AS (OR: 3.17, 3.66, 4.011). Conclusions: Due to the close relationship of PTPN22 and AS, the study may be helpful for the early diagnosis and differential diagnosis.
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页码：933 / 937
页数：5
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