Microwave Promoted Simple, Efficient and Regioselective Synthesis of Trisubstituted Imidazo[1,2-a]benzimidazoles on Soluble Support

被引：6

作者：

Chen, Li-Hsun ^{[1
]}

Hsiao, Ya-Shan ^{[1
]}

Yellol, Gorakh S. ^{[1
]}

Sun, Chung-Ming ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu 30010, Taiwan

来源：

ACS COMBINATORIAL SCIENCE | 2011年 / 13卷 / 02期

关键词：

microwave-assisted; polymer-supported; amino benzimidazoles; biologically interesting; GUANIDINE;

D O I：

10.1021/co1000037

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient microwave-assisted and soluble polymer-supported synthesis of medicinally important imidazole-fused benzimidazoles has been developed. The protocol involves the rapid condensation of polymer-bound amino benzimidazoles with various alpha-bromoke-tones and subsequent in, situ intramolecular cyclization under microwave irradiation resulting in a one pot synthesis of imidazole interlacing benzimidazole polymer conjugates. The condensed product was obtained with excellent regioselectivity. The biologically interesting imidazo [1,2-a]benzimidazoles was released from polymer support at ambient temperature. Diversity in the triheterocyclic nucleus was achieved by the different substitutions at its 2, 3, and 9 positions. The new protocol has the advantages of short reaction time, easy workup process, excellent yields, reduced environmental impact, wide substrate scope and convenient procedure.

引用

页码：112 / 119

页数：8

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