Androgens promote preosteoblast differentiation via activation of the canonical Wnt signaling pathway

被引：15
作者：
Liu, Xin-Hua [1 ]
Kirschenbaum, Alexander [2 ]
Yao, Shen
Levine, Alice C.
机构：
[1] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Urol, New York, NY 10029 USA
来源：
SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING | 2007年 / 1116卷
关键词：
androgens; preosteoblasts; Wnt signaling;
D O I：
10.1196/annals.1402.017
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although androgens stimulate bone formation the precise events underlying these effects have not been elucidated. Wnt signaling plays a central role in osteoblast development and bone formation. We demonstrated that dihydrotestosterone (DHT) significantly stimulates MC3T3 preosteoblast differentiation with no effect on cell growth. This effect of DHT was accompanied by increased Wnt signaling in the same cells. Moreover, the stimulatory effects of DHT on preosteoblast differentiation were inhibited by overexpression of soluble frizzed-related protein (sFRP), a naturally occurring Wnt antagonist. These results suggest that androgens promote preosteoblastic differentiation via effects on the canonical Wnt signaling pathway.
引用
收藏
页码：423 / 431
页数：9
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  • [1] Effects of dihydrotestosterone alone and combined with estrogen on bone mineral density, bone growth, and formation rates in ovariectomized rats
    Coxam, V
    Bowman, BM
    Mecham, M
    Roth, CM
    Miller, MA
    Miller, SC
    [J]. BONE, 1996, 19 (02) : 107 - 114
  • [2] INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN-MEDIATED BY PROTEIN-KINASE-B
    CROSS, DAE
    ALESSI, DR
    COHEN, P
    ANDJELKOVICH, M
    HEMMINGS, BA
    [J]. NATURE, 1995, 378 (6559) : 785 - 789
  • [3] Effects of dihydrotestrone on osteoblast gene expression in osteopenic ovariectomized rats
    Davey, RA
    Morris, HA
    [J]. ENDOCRINE RESEARCH, 2004, 30 (03) : 361 - 368
  • [4] Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression
    Gaur, T
    Lengner, CJ
    Hovhannisyan, H
    Bhat, RA
    Bodine, PVN
    Komm, BS
    Javed, A
    van Wijnen, AJ
    Stein, JL
    Stein, GS
    Lian, JB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (39) : 33132 - 33140
  • [5] Androgen effects on bone metabolism: recent progress and controversies
    Hofbauer, LC
    Khosla, S
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1999, 140 (04) : 271 - 286
  • [6] ANDROGENS DIRECTLY STIMULATE PROLIFERATION OF BONE-CELLS INVITRO
    KASPERK, CH
    WERGEDAL, JE
    FARLEY, JR
    LINKHART, TA
    TURNER, RT
    BAYLINK, DJ
    [J]. ENDOCRINOLOGY, 1989, 124 (03) : 1576 - 1578
  • [7] Cross-talk between the interleukin-6 and prostaglandin E2 signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-κB (RANK) ligand/RANK system
    Liu, XH
    Kirschenbaum, A
    Yao, S
    Levine, AC
    [J]. ENDOCRINOLOGY, 2005, 146 (04) : 1991 - 1998
  • [8] Androgen-induced Wnt signaling in preosteoblasts promotes the growth of MDA-PCa-2b human prostate cancer cells
    Liu, Xin-Hua
    Kirschenbaum, Alexander
    Yao, Shen
    Liu, Guizhong
    Aaronson, Stuart A.
    Levine, Alice C.
    [J]. CANCER RESEARCH, 2007, 67 (12) : 5747 - 5753
  • [9] Wnt signaling in osteoblasts and bone diseases
    Westendorf, JJ
    Kahler, RA
    Schroeder, TM
    [J]. GENE, 2004, 341 : 19 - 39
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