Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer

被引：62

作者：

De Marchi, Tommaso ^{[1
]}

Foekens, John A. ^{[1
]}

Umar, Arzu ^{[1
]}

Martens, John W. M. ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands

来源：

DRUG DISCOVERY TODAY | 2016年 / 21卷 / 07期

关键词：

GENE SIGNATURE PREDICTS; EPIDERMAL-GROWTH-FACTOR; TAMOXIFEN-RESISTANCE; DNA METHYLATION; ESR1; MUTATIONS; TRANSCRIPTIONAL ACTIVITY; COACTIVATOR AIB1; DRUG-RESISTANCE; CROSS-TALK; RNA-SEQ;

D O I：

10.1016/j.drudis.2016.05.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Estrogen receptor (ER)-positive breast cancer represents the majority (similar to 70%) of all breast malignancies. In this subgroup of breast cancers, endocrine therapies are effective both in the adjuvant and recurrent settings, although resistance remains a major issue. Several high-throughput approaches have been used to elucidate mechanisms of resistance and to derive potential predictive markers or alternative therapies. In this review, we cover the state-of-the-art of endocrine-resistance biomarker discovery with regard to the latest technological developments, and discuss current opportunities and restrictions for their implementation into a clinical setting.

引用

页码：1181 / 1188

页数：8

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