Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan

被引：53

作者：

Sugauchi, Fuminaka

Orito, Etsuro

Ohno, Tomoyoshi

Tanaka, Yasuhito

Ozasa, Atsushi

Kang, Jong-Hon

Toyoda, Joji

Kuramitsu, Tomoyuki

Suzuki, Kazuyuki

Tanaka, Eiji

Akahane, Yoshihiro

Ichida, Takafumi

Izumi, Namiki

Inoue, Kazuaki

Hoshino, Hiromi

Iino, Shiro

Yotsuyanagi, Hiroshi

Kakumu, Shinichi

Tomita, Eiichi

Okanoue, Takeshi

Nishiguchi, Shuhei

Murawaki, Yoshikazu

Hino, Keisuke

Onji, Morikazu

Yatsuhashi, Hiroshi

Sata, Michio

Miyakawa, Yuzo

Ueda, Ryuzo

Mizokami, Masashi ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Clin Mol Informat Med, Nagoya, Aichi 4678601, Japan

[2] Nagoya City Univ, Grad Sch Med Sci, Dept Internal Med & Mol Sci, Nagoya, Aichi 4678601, Japan

[3] Teinekeijinkai Hosp, Sappolo, Japan

[4] Sapporo Kosei Gen Hosp, Sappro, Japan

[5] Akita City Hosp, Akita, Japan

[6] Iwate Med Univ, Morioka, Iwate 020, Japan

[7] Shinshu Univ, Grad Sch Med, Matsumoto, Nagano 390, Japan

[8] Univ Yamanashi, Yamanashi, Japan

[9] Juntendo Univ, Sch Med, Shizuoka Hosp, Dept Gastroenterol, Shizuoka, Japan

[10] Musashino Red Cross Hosp, Tokyo, Japan

[11] Showa Univ, Fujigaoka Hosp, Yokohama, Kanagawa 227, Japan

[12] Hepatitis Res Inst, Tokorozawa, Saitama, Japan

[13] Kiyokawa Hosp, Tokyo, Japan

[14] St Marianna Univ, Sch Med, Kawasaki, Kanagawa, Japan

[15] Aichi Med Univ, Sch Med, Aichi, Japan

[16] Gifu Municipal Hosp, Gifu, Japan

[17] Osaka City Univ, Osaka 558, Japan

[18] Tottori Univ, Tottori 680, Japan

[19] Yamaguchi Univ, Sch Med, Yamaguchi, Japan

[20] Ehime Univ, Sch Med, Matsuyama, Ehime, Japan

[21] Natl Hosp Org, Nagasaki Med Ctr, Nagasaki, Japan

[22] Kurume Univ, Sch Med, Kurume, Fukuoka 830, Japan

[23] Miyakawa Mem Res Fdn, Tokyo, Japan

[24] Kyoto Prefectural Univ Med, Kyoto, Japan

来源：

HEPATOLOGY RESEARCH | 2006年 / 36卷 / 02期

关键词：

chronic hepatitis; fulminant hepatitis; hepatitis B e antigen; hepatitis B surface antigen; sexual transmission;

D O I：

10.1016/j.hepres.2006.06.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Genotypes of hepatitis B virus (HBV) were determined in 485 patients with acute hepatitis B from all over Japan. They were A in 92 (19%), Ba in 26 (5%), Bj in 32 (7%), C in 330 (68%) and D in 5 (1%). Sexual contacts were the main route of transmission in them. Overall, HBV persisted in only 5 of the 464 (1%) followed patients. Genotypes C accounted for more than 68% in northern as well as southern areas, contrasting with genotype A accounting for 34% in and around the Metropolitan areas. During 24 years from 1982 to 2005, genotype A increased from 5% to 33%, while genotype B gradually decreased from 26% to 8%. Fulminant hepatitis was significantly more frequent in infection with genotype Bj (41%) than those with the other genotypes (p<0.01). The core-promoter double mutation (T1762/A1764) and precore stop-codon mutation (A1896) were more frequent in patients with fulminant than acute self-limited hepatitis (57% versus 15% and 58% versus 10%, respectively, p<0.01 for both). In conclusion, genotype A distributes unevenly over Japan, prevails in younger patients through sexual transmission and has increased with years. Furthermore, fulminant outcome was more frequent in patients with genotype Bj than those with the other genotypes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：107 / 114

页数：8

共 54 条

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