Sex bias in autism: new insights from Chd8 mutant mice?

被引：9
作者：
Andreae, Laura C. [1 ,2 ]
Basson, M. Albert [1 ,3 ]
机构：
[1] Kings Coll London, MRC Ctr Neurodev Disorders, London, England
[2] Kings Coll London, Ctr Dev Neurobiol, London, England
[3] Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
来源：
NATURE NEUROSCIENCE | 2018年 / 21卷 / 09期
基金：
英国医学研究理事会;
关键词：
NEURODEVELOPMENTAL DISORDERS; GENE-EXPRESSION; MODEL; CIRCUITS; MOUSE; RATIO;
D O I：
10.1038/s41593-018-0217-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A study has found that young male mice with a mutation of the autism-associated gene Chd8 show abnormal behaviors and elevated neuronal activation in several brain areas under stressful conditions, while female mice with the same mutation have reduced baseline neuronal activity, which may protect them from developing these abnormal phenotypes.
引用
收藏
页码：1144 / 1146
页数：4
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共 15 条
  • [1] Sex Differences and Autism: Brain Function during Verbal Fluency and Mental Rotation
    Beacher, Felix D. C. C.
    Radulescu, Eugenia
    Minati, Ludovico
    Baron-Cohen, Simon
    Lombardo, Michael V.
    Lai, Meng-Chuan
    Walker, Anne
    Howard, Dawn
    Gray, Marcus A.
    Harrison, Neil A.
    Critchley, Hugo D.
    [J]. PLOS ONE, 2012, 7 (06):
  • [2] Germline Chd8 haploinsufficiency alters brain development in mouse
    Gompers, Andrea L.
    Su-Feher, Linda
    Ellegood, Jacob
    Copping, Nycole A.
    Riyadh, M. Asrafuzzaman
    Stradleigh, Tyler W.
    Pride, Michael C.
    Schaffler, Melanie D.
    Wade, A. Ayanna
    Catta-Preta, Rinaldo
    Zdilar, Iva
    Louis, Shreya
    Kaushik, Gaurav
    Mannion, Brandon J.
    Plajzer-Frick, Ingrid
    Afzal, Veena
    Visel, Axel
    Pennacchio, Len A.
    Dickel, Diane E.
    Lerch, Jason P.
    Crawley, Jacqueline N.
    Zarbalis, Konstantinos S.
    Silverman, Jill L.
    Nord, Alex S.
    [J]. NATURE NEUROSCIENCE, 2017, 20 (08) : 1062 - +
  • [3] Circuit level defects in the developing neocortex of Fragile X mice
    Goncalves, J. Tiago
    Anstey, James E.
    Golshani, Peyman
    Portera-Cailliau, Carlos
    [J]. NATURE NEUROSCIENCE, 2013, 16 (07) : 903 - U166
  • [4] Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders
    Grissom, N. M.
    McKee, S. E.
    Schoch, H.
    Bowman, N.
    Havekes, R.
    O'Brien, W. T.
    Mahrt, E.
    Siegel, S.
    Commons, K.
    Portfors, C.
    Nickl-Jockschat, T.
    Reyes, T. M.
    Abel, T.
    [J]. MOLECULAR PSYCHIATRY, 2018, 23 (03) : 544 - 555
  • [5] A Higher Mutational Burden in Females Supports a "Female Protective Model" in Neurodevelopmental Disorders
    Jacquemont, Sebastien
    Coe, Bradley P.
    Hersch, Micha
    Duyzend, Michael H.
    Krumm, Niklas
    Bergmann, Sven
    Beckmann, Jacques S.
    Rosenfeld, Jill A.
    Eichler, Evan E.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2014, 94 (03) : 415 - 425
  • [6] Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice
    Jung, Hwajin
    Park, Haram
    Choi, Yeonsoo
    Kang, Hyojin
    Lee, Eunee
    Kweon, Hanseul
    Roh, Junyeop Daniel
    Ellegood, Jacob
    Choi, Woochul
    Kang, Jaeseung
    Rhim, Issac
    Choi, Su-Yeon
    Bae, Mihyun
    Kim, Sun-Gyun
    Lee, Jiseok
    Chung, Changuk
    Yoo, Taesun
    Park, Hanwool
    Kim, Yangsik
    Ha, Seungmin
    Um, Seung Min
    Mo, Seojung
    Kwon, Yonghan
    Mah, Won
    Bae, Yong Chul
    Kim, Hyun
    Lerch, Jason P.
    Paik, Se-Bum
    Kim, Eunjoon
    [J]. NATURE NEUROSCIENCE, 2018, 21 (09) : 1218 - +
  • [7] CHD8 haploinsufficiency results in autistic-like phenotypes in mice
    Katayama, Yuta
    Nishiyama, Masaaki
    Shoji, Hirotaka
    Ohkawa, Yasuyuki
    Kawamura, Atsuki
    Sato, Tetsuya
    Suyama, Mikita
    Takumi, Toru
    Miyakawa, Tsuyoshi
    Nakayama, Keiichi I.
    [J]. NATURE, 2016, 537 (7622) : 675 - +
  • [8] Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism
    Kim, Yongsoo
    Yang, Guangyu Robert
    Pradhan, Kith
    Venkataraju, Kannan Umadevi
    Bota, Mihail
    del Molino, Luis Carlos Garcia
    Fitzgerald, Greg
    Ram, Keerthi
    He, Miao
    Levine, Jesse Maurica
    Mitra, Partha
    Huang, Z. Josh
    Wang, Xiao-Jing
    Osten, Pavel
    [J]. CELL, 2017, 171 (02) : 456 - +
  • [9] What Is the Male-to-Female Ratio in Autism Spectrum Disorder? A Systematic Review and Meta-Analysis
    Loomes, Rachel
    Hull, Laura
    Mandy, William Polmear Locke
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2017, 56 (06) : 466 - 474
  • [10] Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B-/- mice
    Peixoto, Rui T.
    Wang, Wengang
    Croney, Donyell M.
    Kozorovitskiy, Yevgenia
    Sabatini, Bernardo L.
    [J]. NATURE NEUROSCIENCE, 2016, 19 (05) : 716 - +
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