Does Attention Constrain Developmental Trajectories in Fragile X Syndrome? A 3-Year Prospective Longitudinal Study

被引:47
作者
Cornish, Kim [2 ]
Cole, Victoria
Longhi, Elena
Karmiloff-Smith, Annette [3 ]
Scerif, Gaia [1 ]
机构
[1] Univ Oxford, Dept Expt Psychol, Attent Brain & Cognit Dev ABCD Grp, Oxford OX1 3UD, England
[2] Monash Univ, Melbourne, Vic 3004, Australia
[3] Univ London, London, England
来源
AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES | 2012年 / 117卷 / 02期
基金
英国惠康基金;
关键词
fragile X syndrome; attention; developmental trajectories; longitudinal; AUTISTIC BEHAVIOR; PARENT SURVEY; YOUNG BOYS; LIFE-SPAN; CHILDREN; DISORDERS; PHENOTYPE; SYMPTOMS; MALES;
D O I
10.1352/1944-7558-117.2.103
中图分类号
G76 [特殊教育];
学科分类号
040109 ;
摘要
Basic attentional processes and their impact on developmental trajectories in fragile X syndrome were assessed in a 3-year prospective study. Although fragile X syndrome is a monogenic X-linked disorder, there is striking variability in outcomes even in young boys with the condition. Attention is a key factor constraining interactions with the environment, so it is a perfect candidate to predict trajectories in cognitive and behavioral outcomes. In this study, 48 boys with fragile X syndrome were assessed 3 times over 24 months. Although nonverbal IQ declined, there were significant improvements in nonverbal growth scores and in cognitive attention. In contrast, behavioral difficulties (i.e., autistic symptomatology, hyperactivity-inattention) remained stable over this time frame. Attentional markers in the visual and auditory modalities predicted intellectual abilities and classroom behavior, whereas auditory markers alone predicted autistic symptomatology.
引用
收藏
页码:103 / +
页数:18
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