A proposal for the mechanism-of-action of diazoparaquinone natural products

被引：29

作者：

Feldman, KS ^{[1
]}

Eastman, KJ ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 44期

关键词：

D O I：

10.1021/ja053880w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Treatment of the representative diazoparaquinone prekinamycin dimethyl ether with Bu3SnH/AIBN in aromatic solvents furnishes moderate-to-good yields of formal aryl adducts wherein a molecule of solvent is attached to the carbon (C(11)) previously bearing the diazo function. Substituent studies provide evidence in support of a radical aromatic substitution mechanism, in which radical addition to the diazoparaquinone function generates an intermediate C(11) vinylic radical. Copyright © 2005 American Chemical Society.

引用

页码：15344 / 15345

页数：2

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