p53 and apoptosis

被引：260

作者：

Gottlieb, TM ^{[1
]}

Oren, M ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

来源：

SEMINARS IN CANCER BIOLOGY | 1998年 / 8卷 / 05期

关键词：

p53; tumor suppressor; apoptosis;

D O I：

10.1006/scbi.1998.0098

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One of the several biological functions attributed to p53 is the ability to induce apoptotic cell suicide. It has become clear that this apoptotic activity of p53 is central to its role as a tumor suppressor. A summary of current knowledge concerning the mechanisms of p53-mediated apoptosis is presented. The pivotal 'choice' between p53-induced viable growth arrest and apoptosis is discussed.

引用

页码：359 / 368

页数：10

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