Lactate: A Metabolic Driver in the Tumour Landscape

被引：376

作者：

Ippolito, Luigi ^{[1
]}

Morandi, Andrea ^{[1
]}

Giannoni, Elisa ^{[1
]}

Chiarugi, Paola ^{[1
]}

机构：

[1] Univ Florence, Dept Expt & Clin Biomed Sci, I-50134 Florence, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2019年 / 44卷 / 02期

关键词：

CANCER-ASSOCIATED FIBROBLASTS; DEHYDROGENASE B; LACTIC-ACID; CELL-METABOLISM; INHIBITION; EXPRESSION; TARGET; CD147; MCT1; MYC;

D O I：

10.1016/j.tibs.2018.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.

引用

页码：153 / 166

页数：14

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