Role and Function of Sphingomyelin Biosynthesis in the Development of Cancer

被引：52

作者：

D'Angelo, Giovanni ^{[1
]}

Moorthi, Sitapriya ^{[2
]}

Luberto, Chiara ^{[2
]}

机构：

[1] Natl Res Council Italy, Inst Prot Biochem, Naples, Italy

[2] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

来源：

SPHINGOLIPIDS IN CANCER | 2018年 / 140卷

关键词：

CERAMIDE TRANSPORT PROTEIN; SYNTHASE; ACTIVITY; PORE-FORMING TOXIN; LIPID RAFTS; ENDOPLASMIC-RETICULUM; CELL-PROLIFERATION; DIFFERENTIAL LOCALIZATION; NONVESICULAR TRAFFICKING; SPHINGOLIPID METABOLISM; MEMBRANE SPHINGOMYELIN;

D O I：

10.1016/bs.acr.2018.04.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sphingomyelin (SM) biosynthesis represents a complex, finely regulated process, mostly occurring in vertebrates. It is intimately linked to lipid transport and it is ultimately carried out by two enzymes, SM synthase 1 and 2, selectively localized in the Golgi and plasma membrane. In the course of the SM biosynthetic reaction, various lipids are metabolized. Because these lipids have both structural and signaling functions, the SM biosynthetic process has the potential to affect diverse important cellular processes (such as cell proliferation, cell survival, and migration). Thus defects in SM biosynthesis might directly or indirectly impact the normal physiology of the cell and eventually of the organism. In this chapter, we will focus on evidence supporting a role for SM biosynthesis in specific cellular functions and how its dysregulation can affect neoplastic transformation.

引用

页码：61 / 96

页数：36

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