Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability

被引：29

作者：

Bajic, Vladan ^{[1
]}

Spremo-Potparevic, Biljana ^{[2
]}

Zivkovic, Lada ^{[2
]}

Isenovic, Esma R. ^{[1
]}

Arendt, Thomas ^{[3
]}

机构：

[1] Univ Belgrade, Inst Nucl Sci Vinca, Lab Radiobiol & Mol Genet, Belgrade 11001, Serbia

[2] Univ Belgrade, Fac Pharm, Inst Physiol, Dept Biol & Human Genet, Belgrade 11000, Serbia

[3] Univ Leipzig, Sch Med, Paul Flechsig Inst Brain Res, D-04109 Leipzig, Germany

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2015年 / 55卷

关键词：

Alzheimer's disease (AD); Aneuploidy; Genomic mosaicism; Cell cycle; Cohesion; PREMATURE CENTROMERE DIVISION; PERIPHERAL-BLOOD LYMPHOCYTES; NEURONAL CELL-DEATH; ANAPHASE-PROMOTING COMPLEX; MILD COGNITIVE IMPAIRMENT; DOWN-SYNDROME; X-CHROMOSOME; DNA-REPLICATION; GENE-EXPRESSION; CYCLE REENTRY;

D O I：

10.1016/j.neubiorev.2015.05.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：365 / 374

页数：10

共 146 条

[41] Chromatid segregation analysis in native human lymphocyte anaphases using sequential fluorescence in situ hybridization [J].

Escudero, T ;

Coll, MD ;

Fuster, C ;

Egozcue, J .

CYTOTECHNOLOGY, 2002, 39 (03) :171-175

[42] Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain [J].

Evrony, Gilad D. ;

Cai, Xuyu ;

Lee, Eunjung ;

Hills, L. Benjamin ;

Elhosary, Princess C. ;

Lehmann, Hillel S. ;

Parker, J. J. ;

Atabay, Kutay D. ;

Gilmore, Edward C. ;

Poduri, Annapurna ;

Park, Peter J. ;

Walsh, Christopher A. .

CELL, 2012, 151 (03) :483-496

[43] The common biology of cancer and ageing [J].

Finkel, Toren ;

Serrano, Manuel ;

Blasco, Maria A. .

NATURE, 2007, 448 (7155) :767-774

[44] EVIDENCE FOR THE REPEATED PRIMARY NONDISJUNCTION OF CHROMOSOME-21 AS A RESULT OF PREMATURE CENTROMERE DIVISION (PCD) [J].

FITZGERALD, PH ;

ARCHER, SA ;

MORRIS, CM .

HUMAN GENETICS, 1986, 72 (01) :58-62

[45] SPINDLE MICROTUBULAR DYSFUNCTION IN MOTHERS OF DOWN SYNDROME CHILDREN [J].

FORD, JH .

HUMAN GENETICS, 1984, 68 (04) :295-298

[46] Altered Cytological Parameters in Buccal Cells from Individuals with Mild Cognitive Impairment and Alzheimer's Disease [J].

Francois, Maxime ;

Leifert, Wayne ;

Hecker, Jane ;

Faunt, Jeffrey ;

Martins, Ralph ;

Thomas, Philip ;

Fenech, Michael .

CYTOMETRY PART A, 2014, 85A (08) :698-708

[47] Dicer is essential for formation of the heterochromatin structure in vertebrate cells [J].

Fukagawa, T ;

Nogami, M ;

Yoshikawa, M ;

Ikeno, M ;

Okazaki, T ;

Takami, Y ;

Nakayama, T ;

Oshimura, M .

NATURE CELL BIOLOGY, 2004, 6 (08) :784-791

[48] Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease [J].

Geller, LN ;

Potter, H .

NEUROBIOLOGY OF DISEASE, 1999, 6 (03) :167-179

[49] Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons [J].

Gieffers, C ;

Peters, BH ;

Kramer, ER ;

Dotti, CG ;

Peters, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11317-11322

[50] Alzheimer Aβ Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP [J].

Granic, Antoneta ;

Padmanabhan, Jaya ;

Norden, Michelle ;

Potter, Huntington .

MOLECULAR BIOLOGY OF THE CELL, 2010, 21 (04) :511-520

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