Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability

被引：29
作者：
Bajic, Vladan [1 ]
Spremo-Potparevic, Biljana [2 ]
Zivkovic, Lada [2 ]
Isenovic, Esma R. [1 ]
Arendt, Thomas [3 ]
机构：
[1] Univ Belgrade, Inst Nucl Sci Vinca, Lab Radiobiol & Mol Genet, Belgrade 11001, Serbia
[2] Univ Belgrade, Fac Pharm, Inst Physiol, Dept Biol & Human Genet, Belgrade 11000, Serbia
[3] Univ Leipzig, Sch Med, Paul Flechsig Inst Brain Res, D-04109 Leipzig, Germany
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2015年 / 55卷
关键词：
Alzheimer's disease (AD); Aneuploidy; Genomic mosaicism; Cell cycle; Cohesion; PREMATURE CENTROMERE DIVISION; PERIPHERAL-BLOOD LYMPHOCYTES; NEURONAL CELL-DEATH; ANAPHASE-PROMOTING COMPLEX; MILD COGNITIVE IMPAIRMENT; DOWN-SYNDROME; X-CHROMOSOME; DNA-REPLICATION; GENE-EXPRESSION; CYCLE REENTRY;
D O I：
10.1016/j.neubiorev.2015.05.010
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：365 / 374
页数：10
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