Ni-Catalyzed Allylic Dearomatization Reaction of β-Naphthols with Allylic Alcohols

被引：25
作者：
Zhang, Hui-Jun [1 ]
Gu, Qing [2 ]
You, Shu-Li [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 08期
基金：
国家重点研发计划;
关键词：
CROSS-COUPLING REACTIONS; ASYMMETRIC DEAROMATIZATION; GRIGNARD-REAGENTS; ENANTIOSELECTIVE DEAROMATIZATION; INTRAMOLECULAR DEAROMATIZATION; SUBSTITUTION-REACTIONS; BOND FORMATION; ALKYLATION; ALLYLATION; PALLADIUM;
D O I：
10.1021/acs.orglett.0c01109
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ni-catalyzed intermolecular allylic dearomatization reaction of beta-naphthols with allylic alcohols was achieved. By utilizing Ni(cod)(2) as a catalyst precursor, DPEphos as a ligand and 4 angstrom molecular sieves as additives, the dearomatization reaction of beta-naphthols with aryl allylic alcohols proceeded smoothly under mild conditions, affording the desired beta-naphthalenone products bearing a quaternary carbon center in moderate to good yields with excellent linear selectivity.
引用
收藏
页码：3297 / 3301
页数：5
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