Structural Modification for Antitumor Nitrogenous Steroids

被引：0

作者：

Xie Tian-Peng ^{[1
]}

Yang Kang ^{[1
]}

Zhang Li-Zhi ^{[1
]}

Chen De-Sheng ^{[1
]}

Zou Kun ^{[1
]}

Huang Nian-Yu ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2017年 / 36卷 / 12期

基金：

中国国家自然科学基金;

关键词：

steroids; structural modification; N-hetercycles; antitumor; structure-activity; VITRO ANTIPROLIFERATIVE EVALUATION; IN-VITRO; ANTICANCER AGENTS; BIOLOGICAL EVALUATION; CHEMICAL-SYNTHESIS; CYTOTOXIC ACTIVITIES; E-SALIGNONE; DERIVATIVES; CANCER; RING;

D O I：

10.14102/j.cnki.0254-5861.2011-1688

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Natural steroids have been showing notable cytotoxic activities, which are quite interesting lead compounds for the development of anticancer drug including estramustine and prednimustine. Considering that these semi-synthetic molecules are nitrogen mustard functionalized steroidal derivatives, the present review is focused on the methodologies of introducing nitrogen atom or nitrogen-containing heterocycles on A similar to D rings or side chains of steroids, and analysis of the structure-activity relationship (SAR) for these man-made cytotoxic steroids.

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页码：2007 / 2019

页数：13

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