Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity

被引：85

作者：

Gao, Ningning ^{[2
]}

Zhang, Qiu ^{[1
]}

Mu, Qingxin ^{[3
]}

Bai, Yuhong ^{[2
]}

Li, Liwen ^{[1
]}

Zhou, Hongyu ^{[3
]}

Butch, Elizabeth R. ^{[4
]}

Powell, Tremaine B. ^{[6
]}

Snyder, Scott E. ^{[4
]}

Jiang, Guibin ^{[5
]}

Yan, Bing ^{[1
,3
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Peoples R China

[3] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Radiol Sci, Memphis, TN 38105 USA

[5] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China

[6] USEPA Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA

来源：

ACS NANO | 2011年 / 5卷 / 06期

基金：

中国国家自然科学基金;

关键词：

multiwalled carbon nanotubes (MWCNTs); immunotoxicity; surface chemistry modification; mannose receptor; scavenger receptor; NF kappa B; OXIDATIVE STRESS; MANNOSE RECEPTOR; IN-VITRO; PULMONARY; TOXICITY; PROTEIN; BIODISTRIBUTION; MECHANISMS; RESPONSES; BINDING;

D O I：

10.1021/nn200283g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbon nanotubes (CNTs) cause perturbations in Immune systems and limit the application of CNTs in biomedidne. Here we demonstrate that a surface chemistry modification on multiwalled CNTs (MWCNTs) reduces their immune perturbations in mice and in macrophages. The modified MWCNTs change their preferred binding pattern from mannose receptor to scavenger receptor. This switch significantly alleviates NF kappa B activation and reduces immunotoxicity of MWCNTs.

引用

页码：4581 / 4591

页数：11

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