Measurement of skeletal muscle mass in Duchenne muscular dystrophy: use of 24-h creatinine excretion

被引：16
作者：
Franciotta, D
Zanardi, MC
Albertotti, L
Orcesi, S
Berardinelli, A
Pichiecchio, A
Uggetti, C
Tagliabue, A
机构：
[1] Univ Pavia, Human Nutr Res Ctr, I-27100 Pavia, Italy
[2] Univ Pavia, Neurol Inst C Mondino, IRCCS Fdn, I-27100 Pavia, Italy
来源：
ACTA DIABETOLOGICA | 2003年 / 40卷 / Suppl 1期
关键词：
skeletal muscle mass; creatinine excretion; magnetic resonance imaging;
D O I：
10.1007/s00592-003-0089-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Creatinine concentration in 24-h urine has been proposed as an indirect measure of body skeletal muscle mass (SMM). We attempted to correlate urinary creatinine levels with SMM in eight patients with Duchenne muscular dystrophy, a progressive disease in which the degree of muscle wasting parallels the rate of progression. Magnetic resonance imaging and a newly developed protocol for image analysis were used for the measurement of SMM. The patients ate a creatine-free diet for the week before urine collection. Creatinine was measured with an enzymatic-colorimetric method. Mean (+/-SD) SMM value was 5.4 +/- 2.5 kg and urine creatinine levels 205.8 +/- 96.4 mg/day. Daily urinary creatinine excretion did not correlate with SMM. The simple creatinine determination in urine cannot predict SMM in Duchenne muscular dystrophy.
引用
收藏
页码：S290 / S292
页数：3
相关论文
共 8 条
[1]   QUANTITATIVE IMPORTANCE OF NON-SKELETAL-MUSCLE N-TAU-METHYLHISTIDINE AND CREATINE IN HUMAN-URINE [J].
AFTING, EG ;
BERNHARDT, W ;
JANZEN, RWC ;
ROTHIG, HJ .
BIOCHEMICAL JOURNAL, 1981, 200 (02) :449-452
[2]   A NEW CHART FOR WEIGHT CONTROL IN DUCHENNE MUSCULAR-DYSTROPHY [J].
GRIFFITHS, RD ;
EDWARDS, RHT .
ARCHIVES OF DISEASE IN CHILDHOOD, 1988, 63 (10) :1256-1258
[3]   THE ASSESSMENT OF MUSCLE MASS IN PROGRESSIVE NEUROMUSCULAR DISEASE [J].
GRIGGS, RC ;
FORBES, G ;
MOXLEY, RT ;
HERR, BE .
NEUROLOGY, 1983, 33 (02) :158-165
[4]   MEASUREMENT OF MUSCLE MASS IN HUMANS - VALIDITY OF THE 24-HOUR URINARY CREATININE METHOD [J].
HEYMSFIELD, SB ;
ARTEAGA, C ;
MCMANUS, C ;
SMITH, J ;
MOFFITT, S .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1983, 37 (03) :478-494
[5]  
Kent-Braun J A, 1995, Exerc Sport Sci Rev, V23, P305
[6]   Quantitative MR evaluation of body composition in patients with Duchenne muscular dystrophy [J].
Pichiecchio, A ;
Uggetti, C ;
Egitto, MG ;
Berardinelli, A ;
Orcesi, S ;
Gorni, KOT ;
Zanardi, C ;
Tagliabue, A .
EUROPEAN RADIOLOGY, 2002, 12 (11) :2704-2709
[7]   Total-body skeletal muscle mass: Evaluation of 24-h urinary creatinine excretion by computerized axial tomography [J].
Wang, ZM ;
Gallagher, D ;
Nelson, ME ;
Matthews, DE ;
Heymsfield, SB .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1996, 63 (06) :863-869
[8]   Body composition and energy expenditure in Duchenne muscular dystrophy [J].
Zanardi, MC ;
Tagliabue, A ;
Orcesi, S ;
Berardinelli, A ;
Uggetti, C ;
Pichiecchio, A .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2003, 57 (02) :273-278
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