In vitro and in vivo study of ion-implanted collagen for the substrate of small diameter artificial grafts

被引：9

作者：

Kurotobi, K

Suzuki, Y

Kaibara, M

Iwaki, M

Nakajima, H

Suzuki, H

机构：

[1] RIKEN, Surface Characterizat Ctr, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[2] Sci Univ Tokyo, Fac Sci, Tokyo 162, Japan

[3] Teikyo Univ, Sch Med, Dept Surg 2, Tokyo 173, Japan

[4] Tokyo Metropolitan Inst Med Sci, Pharmaceut R&D Ctr, Tokyo 113, Japan

来源：

ARTIFICIAL ORGANS | 2003年 / 27卷 / 06期

关键词：

collagen; antithrombogenicity; platelet adhesion; washed platelet; ion implantation; artificial vascular graft;

D O I：

10.1046/j.1525-1594.2003.07016.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Ion implantation into the collagen-coated inner surface of the grafts was performed and evaluated in vitro and in vivo to develop small diameter artificial vascular grafts. He+ ion implanted collagen-coated grafts with a fluence of 1 x 10(14) ions/cm(2) inhibited platelet adhesion and demonstrated patency for 240 days in an animal study. The platelet adhesion test using platelet rich plasma (PRP) showed antithrombogenicity at the fluence of 1 x 10(14) ions/cm(2) . Washed platelet adhesion test showed thrombus formation at the fluence of 1 x 10(14) ions/cm(2) . The results suggested that plasma protein adsorption onto the ion-implanted collagen significantly improved performance of these synthetic grafts.

引用

页码：582 / U2

页数：5

共 5 条

[1] The collagen-binding A-domains of integrins α1β1 and α2β1 recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens [J].