The Study Team for Early Life Asthma Research (STELAR) consortium 'Asthma e-lab': team science bringing data, methods and investigators together

被引:51
作者
Custovic, Adnan [1 ,2 ]
Ainsworth, John [3 ]
Arshad, Hasan [4 ,5 ,6 ]
Bishop, Christopher [7 ]
Buchan, Iain [3 ]
Cullinan, Paul [8 ]
Devereux, Graham [9 ]
Henderson, John [10 ]
Holloway, John [5 ]
Roberts, Graham [4 ,6 ,11 ]
Turner, Steve [9 ]
Woodcock, Ashley [1 ,2 ]
Simpson, Angela [1 ,2 ]
机构
[1] Univ Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester M23 9LT, Lancs, England
[2] Univ S Manchester Hosp, Manchester, Lancs, England
[3] Univ Manchester, Inst Populat Hlth, Ctr Hlth Informat, Manchester M23 9LT, Lancs, England
[4] St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England
[5] Univ Southampton, Fac Med, Clin & Expt Sci Acad Unit, Southampton SO9 5NH, Hants, England
[6] Univ Hosp Southampton NHS Fdn Trust, NIHR Resp Biomed Res Unit, Southampton, Hants, England
[7] Microsoft Res Cambridge, Cambridge, England
[8] Univ London Imperial Coll Sci Technol & Med, London, England
[9] Univ Aberdeen, Child Hlth, Aberdeen, Scotland
[10] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England
[11] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO9 5NH, Hants, England
关键词
WHEEZE PHENOTYPES;
D O I
10.1136/thoraxjnl-2015-206781
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
We created Asthma e-Lab, a secure web-based research environment to support consistent recording, description and sharing of data, computational/statistical methods and emerging findings across the five UK birth cohorts. The e-Lab serves as a data repository for our unified dataset and provides the computational resources and a scientific social network to support collaborative research. All activities are transparent, and emerging findings are shared via the e-Lab, linked to explanations of analytical methods, thus enabling knowledge transfer. eLab facilitates the iterative interdisciplinary dialogue between clinicians, statisticians, computer scientists, mathematicians, geneticists and basic scientists, capturing collective thought behind the interpretations of findings.
引用
收藏
页码:799 / 801
页数:3
相关论文
共 5 条
[1]  
[Anonymous], 2006, LANCET, V368, P705
[2]   Why linked data is not enough for scientists [J].
Bechhofer, Sean ;
Buchan, Iain ;
De Roure, David ;
Missier, Paolo ;
Ainsworth, John ;
Bhagat, Jiten ;
Couch, Philip ;
Cruickshank, Don ;
Delderfield, Mark ;
Dunlop, Ian ;
Gamble, Matthew ;
Michaelides, Danius ;
Owen, Stuart ;
Newman, David ;
Sufi, Shoaib ;
Goble, Carole .
FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE, 2013, 29 (02) :599-611
[3]  
Belgrave D, 2014, AM J RESP CRIT CARE, V189, P121, DOI 10.1164/rccm.201312-2206ED
[4]   Developmental Profiles of Eczema, Wheeze, and Rhinitis: Two Population-Based Birth Cohort Studies [J].
Belgrave, Danielle C. M. ;
Granell, Raquel ;
Simpson, Angela ;
Guiver, John ;
Bishop, Christopher ;
Buchan, Iain ;
Henderson, A. John ;
Custovic, Adnan .
PLOS MEDICINE, 2014, 11 (10)
[5]   Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management [J].
Belgrave, Danielle C. M. ;
Custovic, Adnan ;
Simpson, Angela .
EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2013, 9 (10) :921-936