Leber's hereditary optic neuropathy triggered by optic neuritis

被引：2

作者：

Wakakura, M ^{[1
]}

Mogi, A ^{[1
]}

Ichibe, Y ^{[1
]}

Okada, K ^{[1
]}

Hasebe, H ^{[1
]}

机构：

[1] HIROSHIMA PREFECTURAL HOSP,DEPT OPHTHALMOL,HIROSHIMA,JAPAN

来源：

NEURO-OPHTHALMOLOGY | 1996年 / 16卷 / 06期

关键词：

Leber's hereditary optic neuropathy; optic neuritis; papillitis; mitochondrial DNA;

D O I：

10.3109/01658109609044637

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We observed a 32-year-old man with repeated bilateral optic papillitis followed by permanent visual loss. The patient had mitochondrial point mutation at nucleotide 11778. Fluorescein angiogram showed dye leakage from each disc at the onset. Following the fourth visual loss, no dye leakage at the disc characterized by circumpapillary microangiopathy could be detected. The patient and the family members examined had the 11778 mutation. Optic neuritis, an ocular disorder, may possibly be an extramitochondrial risk factor for the onset of LHON.

引用

页码：337 / 341

页数：5

共 18 条

[1] A RANDOMIZED, CONTROLLED TRIAL OF CORTICOSTEROIDS IN THE TREATMENT OF ACUTE OPTIC NEURITIS [J].

BECK, RW ;

CLEARY, PA ;

ANDERSON, MM ;

KELTNER, JL ;

SHULTS, WT ;

KAUFMAN, DI ;

BUCKLEY, EG ;

CORBETT, JJ ;

KUPERSMITH, MJ ;

MILLER, NR ;

SAVINO, PJ ;

GUY, JR ;

TROBE, JD ;

MCCRARY, JA ;

SMITH, CH ;

CHROUSOS, GA ;

THOMPSON, HS ;

KATZ, BJ ;

BRODSKY, MC ;

GOODWIN, JA ;

ATWELL, CW .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (09) :581-588

[2] OPTIC NEURITIS TREATMENT TRIAL - ONE-YEAR FOLLOW-UP RESULTS [J].

BECK, RW ;

CLEARY, PA .

ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (06) :773-775

[3] LEBERS OPTIC NEUROPATHY CLINICAL AND VISUAL EVOKED-POTENTIAL STUDY OF AFFECTED AND ASYMPTOMATIC MEMBERS OF A 6 GENERATION FAMILY [J].

CARROLL, WM ;

MASTAGLIA, FL .

BRAIN, 1979, 102 (SEP) :559-580

[4] LEBERS HEREDITARY OPTIC NEUROPATHY MASQUERADING AS TOBACCO-ALCOHOL AMBLYOPIA [J].

CULLOM, ME ;

HEHER, KL ;

MILLER, NR ;

SAVINO, PJ ;

JOHNS, DR .

ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (11) :1482-1485

[5]

DEBOIS LG, 1992, J CLIN NEUROPHTHALMO, V12, P15

[6] ASSOCIATION OF THE 11778 MITOCHONDRIAL-DNA MUTATION AND DEMYELINATING DISEASE [J].

FLANIGAN, KM ;

JOHNS, DR .

NEUROLOGY, 1993, 43 (12) :2720-2722

[7] OCCURRENCE OF A MULTIPLE SCLEROSIS-LIKE ILLNESS IN WOMEN WHO HAVE A LEBERS HEREDITARY OPTIC NEUROPATHY MITOCHONDRIAL-DNA MUTATION [J].

HARDING, AE ;

SWEENEY, MG ;

MILLER, DH ;

MUMFORD, CJ ;

KELLARWOOD, H ;

MENARD, D ;

MCDONALD, WI ;

COMPSTON, DAS .

BRAIN, 1992, 115 :979-989

[8] LEBERS HEREDITARY OPTIC NEUROPATHY - CLINICAL MANIFESTATIONS OF THE 14484 MUTATION [J].

JOHNS, DR ;

HEHER, KL ;

MILLER, NR ;

SMITH, KH .

ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (04) :495-498

[9] LEBERS HEREDITARY OPTIC NEUROPATHY MITOCHONDRIAL-DNA MUTATIONS IN MULTIPLE-SCLEROSIS [J].

KELLARWOOD, H ;

ROBERTSON, N ;

GOVAN, GG ;

COMPSTON, DAS ;

HARDING, AE .

ANNALS OF NEUROLOGY, 1994, 36 (01) :109-112

[10] BASE-LINE VISUAL-FIELD PROFILE OF OPTIC NEURITIS - THE EXPERIENCE OF THE OPTIC NEURITIS TREATMENT TRIAL [J].

KELTNER, JL ;

JOHNSON, CA ;

SPURR, JO ;

BECK, RW .

ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (02) :231-234

← 1 2 →