Pathophysiological mechanisms of hemorrhagic stroke and the ways of differential therapy

被引：0

作者：

Gusev, E. I.

Stonik, V. A.

Martynov, M. Yu.

Guseva, M. R.

Shchukin, I. A.

Dyuizen, I. V.

Koplik, E. V.

Mishchenko, N. P.

Agafonova, I. G.

Kolesnikova, T. I.

Fedoreev, S. A.

机构：

来源：

ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2007年

关键词：

hemorrhagic stroke; blood rheological properties; antioxidant and chelate therapy;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The changes developing in the perifocal area of hematoma and perspectives of antioxidant and chelate therapy were studied on the model of experimental hemorrhagic stroke and in clinical conditions. Microcirculatory, ischemic and inflammation disturbances with a certain time sequence were found in the perifocal areas. These changes, along with hypostasis and oxidative stress, form the pathobiochemical cascade of changes in hemorrhagic stroke and are potential therapeutic targets. Administering of an antioxidant and chelate drug histochrome reduces the intensity of changes in the perifocal area in the experimental conditions. in clinical conditions, it accelerates the dynamics of brain and meningeal symptoms regression and improves the blood rheological properties.

引用

页码：10 / 15

页数：6

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