Cobalt-Catalyzed Twofold Direct C(sp2)-C(sp3) Bond Coupling: Regioselective C-3 Alkylation of Coumarins with (Cyclo)alkyl Ethers

被引：37

作者：

Dian, Longyang ^{[1
]}

Zhao, Hui ^{[2
]}

Zhang-Negrerie, Daisy ^{[1
]}

Du, Yunfei ^{[1
]}

机构：

[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China

[2] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 15期

基金：

美国国家科学基金会;

关键词：

(cyclo)alkyl ethers; C-H bond functionalization; coumarins; mild conditions; twofold bond coupling; C-H FUNCTIONALIZATION; 4-ARYLCOUMARIN ANALOGS; CROSS-COUPLINGS; 4-SUBSTITUTED COUMARINS; 4-PHENYLCOUMARINS; COMBRETASTATINS; ALKENYLATION; CELLS;

D O I：

10.1002/adsc.201600349

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A cobalt-catalyzed regioselective C-3 alkylation of coumarins was realized under mild reaction conditions, during which a variety of substituted coumarins including those containing sensitive functional groups could smoothly undergo the selective C(sp(2))-C(sp(3)) bond formation with a series of cyclic or straight-chain alkyl ethers.

引用

页码：2422 / 2426

页数：5

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