Sulfite-Promoted Synthesis of N-Difluoromethylthioureas via the Reaction of Azoles with Bromodifluoroacetate and Elemental Sulfur

被引：29
作者：
Deng, Jian-Chao [1 ]
Gao, Yong-Chao [1 ]
Zhu, Zhu [1 ]
Xu, Li [1 ]
Li, Zhao-Dong [1 ]
Tang, Ri-Yuan [1 ,2 ]
机构：
[1] South China Agr Univ, Coll Mat & Energy, Dept Appl Chem, Guangzhou 510642, Guangdong, Peoples R China
[2] South China Agr Univ, Minist Educ, Key Lab Nat Pesticide & Chem Biol, Guangzhou 510642, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 02期
关键词：
C-H DIFLUOROMETHYLATION; REAGENT; DIFLUOROCARBENE; IMIDAZOPYRIDINES; IMIDAZOLES; ACCESS; ARENES; COPPER;
D O I：
10.1021/acs.orglett.8b03876
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A sulfite-promoted transformation of azoles into N-difluoromethylthioureas through N-difluoromethylation and sulfuration has been developed. In this reaction, inexpensive ethyl bromodifluoroacetate and nontoxic elemental sulfur were used as the difluoromethylation and sulfuration reagents, respectively. A variety of azoles, including benzimidazoles, imidazoles, and triazoles, performed well to afford a broad range of azole thioureas in moderate to good yields.
引用
收藏
页码：545 / 548
页数：4
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