Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment

被引：50

作者：

Xu, Yuanxin ^{[1
,2
]}

Feng, Kuanhan ^{[1
,2
]}

Zhao, Huacong ^{[1
,2
]}

Di, Liuqing ^{[1
,2
]}

Wang, Lei ^{[3
]}

Wang, Ruoning ^{[1
,2
]}

机构：

[1] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China

[2] Jiangsu Prov TCM Engn Technol Res Ctr High Effici, Nanjing 210023, Peoples R China

[3] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China

来源：

THERANOSTICS | 2022年 / 12卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Tumor-derived extracellular vesicles; Drug delivery systems; Cancer therapy; Exosomes; Clinical research progress; THERAPY RECENT ADVANCES; SURFACE FUNCTIONALIZATION; ENGINEERING EXOSOMES; DELIVERY-SYSTEMS; HUMAN PLASMA; BIOLOGY; BIOGENESIS; CELLS; MICROENVIRONMENT; ANGIOGENESIS;

D O I：

10.7150/thno.67775

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Extracellular vesicles (EVs) are kinds of two-layer vesicles secreted by cells. They play significant roles in mediating component exchange between cells, signal transduction, and pathological development. Among them, the tumor-derived EVs (TDEVs) are found related to the tumor microenvironment and cancer development. TDEVs can be designed as a natural drug carrier with high tumor targeting and permeability. In recent years, drug delivery systems (DDS) based on TDEVs for cancer treatments have received considerable attention. In this review, the biological characteristics of TDEVs are introduced, especially the effect on the tumor. Furthermore, the various approaches to constructing DDS based on TDEVs are summarized. Then we listed examples of TDEVs successfully constructing treatment systems. The use of chemical drugs, biological drugs, and engineered drugs as encapsulated drugs are respectively introduced, particularly the application progress of active ingredients in traditional Chinese medicine. Finally, this article introduces the latest clinical research progress, especially the marketed preparations and challenges of clinical application of TDEVs.

引用

页码：1683 / 1714

页数：32

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