Haemophagocytic lymphohistiocytosis associated with immune checkpoint inhibitors: a descriptive case study and literature review

被引：32

作者：

Dupre, Anastasia ^{[1
]}

Michot, Jean-Marie ^{[2
]}

Schoeffler, Amelie ^{[3
]}

Frumholtz, Laure ^{[4
]}

Baroudjian, Barouyr ^{[4
]}

Delyon, Julie ^{[4
,5
]}

Lebbe, Celeste ^{[4
,5
]}

Lambotte, Olivier ^{[1
,6
]}

机构：

[1] Univ Paris Saclay, Hop Bicetre, AP HP, Serv Med Interne & Immunol Clin, Paris, France

[2] Gustave Roussy, DITEP, Villejuif, France

[3] CHR Metz Thionville, Serv Dermatol, Paris, France

[4] Hop St Louis, AP HP, Serv Dermatol, Paris, France

[5] Univ Paris, St Louis Hosp, AP HP, INSERM,U976,Dermatol, Paris, France

[6] Univ Paris Saclay, INSERM, CEA, Ctr Rech Immunol Infect Virales & Malad Autoimmun, Le Kremlin Bicetre, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 189卷 / 05期

关键词：

tumour immunotherapy; haemophagocytic lymphohistiocytosis; haematotoxicity; BLOCKADE;

D O I：

10.1111/bjh.16630

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：985 / 992

页数：8

共 9 条

[1] Haemophagocytic lymphohistiocytosis complicating pembrolizumab treatment for metastatic breast cancer in a patient with the PRF1A91V gene polymorphism [J].

Al-Samkari, Hanny ;

Snyder, Gregory D. ;

Nikiforow, Sarah ;

Tolaney, Sara M. ;

Freedman, Rachel A. ;

Losman, Julie-Aurore .

JOURNAL OF MEDICAL GENETICS, 2019, 56 (01) :39-42

[2] Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome [J].

Fardet, Laurence ;

Galicier, Lionel ;

Lambotte, Olivier ;

Marzac, Christophe ;

Aumont, Cedric ;

Chahwan, Doumit ;

Coppo, Paul ;

Hejblum, Gilles .

ARTHRITIS & RHEUMATOLOGY, 2014, 66 (09) :2613-2620

[3] Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors [J].

Hargadon, Kristian M. ;

Johnson, Coleman E. ;

Williams, Corey J. .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 62 :29-39

[4] Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH [J].

Hayden, Anna ;

Lin, Molly ;

Park, Sujin ;

Pudek, Morris ;

Schneider, Marion ;

Jordan, Michael B. ;

Mattman, Andre ;

Chen, Luke Y. C. .

BLOOD ADVANCES, 2017, 1 (26) :2529-2534

[5] HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].

Henter, Jan-Inge ;

Horne, AnnaCarin ;

Arico, Maurizio ;

Egeler, R. Maarten ;

Filipovich, Alexandra H. ;

Imashuku, Shinsaku ;

Ladisch, Stephan ;

McClain, Ken ;

Webb, David ;

Winiarski, Jacek ;

Janka, Gritta .

PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131

[6] Recommendations for the management of hemophagocytic lymphohistiocytosis in adults [J].

La Rosee, Paul ;

Horne, AnnaCarin ;

Hines, Melissa ;

Greenwood, Tatiana von Bahr ;

Machowicz, Rafal ;

Berliner, Nancy ;

Birndt, Sebastian ;

Gil-Herrera, Juana ;

Girschikofsky, Michael ;

Jordan, Michael B. ;

Kumar, Ashish ;

van Laar, Jan A. M. ;

Lachmann, Gunnar ;

Nichols, Kim E. ;

Ramanan, Athimalaipet, V ;

Wang, Yini ;

Wang, Zhao ;

Janka, Gritta ;

Henter, Jan-Inge .

BLOOD, 2019, 133 (23) :2465-2477

[7] Nivolumab treatment of relapsed/refractory Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults [J].

Liu, Pengpeng ;

Pan, Xiangyu ;

Chen, Chong ;

Niu, Ting ;

Shuai, Xiao ;

Wang, Jian ;

Chen, Xuelan ;

Liu, Jiazhuo ;

Guo, Yong ;

Xie, Liping ;

Wu, Yu ;

Liu, Yu ;

Liu, Ting .

BLOOD, 2020, 135 (11) :826-833

[8] Immune-related adverse events with immune checkpoint blockade: a comprehensive review [J].

Michot, J. M. ;

Bigenwald, C. ;

Champiat, S. ;

Collins, M. ;

Carbonnel, F. ;

Postel-Vinay, S. ;

Berdelou, A. ;

Varga, A. ;

Bahleda, R. ;

Hollebecque, A. ;

Massard, C. ;

Fuerea, A. ;

Ribrag, V. ;

Gazzah, A. ;

Armand, J. P. ;

Amellal, N. ;

Angevin, E. ;

Noel, N. ;

Boutros, C. ;

Mateus, C. ;

Robert, C. ;

Soria, J. C. ;

Marabelle, A. ;

Lambotte, O. .

EUROPEAN JOURNAL OF CANCER, 2016, 54 :139-148

[9] Prognostic Factors and Outcomes of Adults With Hemophagocytic Lymphohistiocytosis [J].

Parikh, Sameer A. ;

Kapoor, Prashant ;

Letendre, Louis ;

Kumar, Shaji ;

Wolanskyj, Alexandra P. .

MAYO CLINIC PROCEEDINGS, 2014, 89 (04) :484-492

← 1 →