Role of hepatic stellate cells in liver ischemia-reperfusion injury

被引：17

作者：

Peng, Yuming ^{[1
,2
]}

Yin, Qiang ^{[1
,2
]}

Yuan, Miaoxian ^{[1
,2
]}

Chen, Lijian ^{[1
,2
]}

Shen, Xinyi ^{[1
,2
]}

Xie, Weixin ^{[1
,2
]}

Liu, Jinqiao ^{[3
]}

机构：

[1] Hunan Childrens Hosp, Dept Gen Surg 1, Changsha, Peoples R China

[2] Zhaolong Chen Academician Workstat, Changsha, Peoples R China

[3] Hunan Childrens Hosp, Dept Ultrasound, Changsha, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

ischemia-reperfusion injury; hepatic stellate cells; hepatocytes; Kupffer cells; neutrophils; sinusoidal endothelial cells; liver transplantation; liver; MATRIX METALLOPROTEASE 9; ISCHEMIA/REPERFUSION INJURY; NONALCOHOLIC STEATOHEPATITIS; REACTIVE OXYGEN; OBETICHOLIC ACID; STEATOTIC LIVER; KUPFFER CELLS; FIBROSIS; RAT; INHIBITOR;

D O I：

10.3389/fimmu.2022.891868

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Liver ischemia-reperfusion injury (IRI) is a major complication of liver trauma, resection, and transplantation. IRI may lead to liver dysfunction and failure, but effective approach to address it is still lacking. To better understand the cellular and molecular mechanisms of liver IRI, functional roles of numerous cell types, including hepatocytes, Kupffer cells, neutrophils, and sinusoidal endothelial cells, have been intensively studied. In contrast, hepatic stellate cells (HSCs), which are well recognized by their essential functions in facilitating liver protection and repair, have gained less attention in their role in IRI. This review provides a comprehensive summary of the effects of HSCs on the injury stage of liver IRI and their associated molecular mechanisms. In addition, we discuss the regulation of liver repair and regeneration after IRI by HSCs. Finally, we highlight unanswered questions and future avenues of research regarding contributions of HSCs to IRI in the liver.

引用

页数：8

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