Micromanaging Vascular Smooth Muscle Cell Differentiation and Phenotypic Modulation

被引:237
|
作者
Davis-Dusenbery, Brandi N. [2 ]
Wu, Connie [3 ]
Hata, Akiko [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA
[2] Tufts Med Ctr, Mol Cardiol Res Inst, Boston, MA USA
[3] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA
关键词
pulmonary hypertension; vascular biology; BMP; TGF-beta; microRNA; MICRORNA; MIR-143; RNA; BIOGENESIS; MATURATION; INDUCTION; MYOCARDIN; MIR-222; PDGF;
D O I
10.1161/ATVBAHA.111.226670
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The phenotype of vascular smooth muscle cells (VSMCs) is dynamically regulated in response to various stimuli. In a cellular process known as phenotype switching, VSMCs alternate between a contractile and synthetic phenotype state. Deregulation of phenotype switching is associated with vascular disorders such as atherosclerosis, restenosis after angioplasty, and pulmonary hypertension. An important role for microRNAs (miRNAs) in VSMC development and phenotype switching has recently been uncovered. Individual miRNAs are involved in promoting both contractile and synthetic VSMC phenotype. In this review, we summarize recent advances in the understanding of miRNA function in the regulation of VSMC phenotype regulation. (Arterioscler Thromb Vasc Biol. 2011;31:2370-2377.)
引用
收藏
页码:2370 / 2377
页数:8
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