MiRNAs-mediated cisplatin resistance in breast cancer

被引：24

作者：

Chen, Xiu ^{[1
,2
,3
]}

Lu, Peng ^{[4
]}

Wu, Ying ^{[5
]}

Wang, Dan-dan ^{[2
,3
]}

Zhou, Siying ^{[2
,3
]}

Yang, Su-jin ^{[1
,2
,3
]}

Shen, Hong-Yu ^{[1
,2
,3
]}

Zhang, Xiao-hui ^{[6
]}

Zhao, Jian-hua ^{[6
]}

Tang, Jin-hai ^{[2
,3
]}

机构：

[1] Nanjing Med Univ, Clin Sch 4, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Gen Surg, Jiangsu Canc Hosp, Baiziting42, Nanjing 210009, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Baiziting42, Nanjing 210009, Peoples R China

[4] Nanjing Med Univ, Sch Publ Hlth, Longmiandadao101, Nanjing, Jiangsu, Peoples R China

[5] Nanjing Med Univ, Clin Sch 1, Baiziting42, Nanjing, Jiangsu, Peoples R China

[6] Nanjing Med Univ, Ctr Clin Lab Sci, Jiangsu Canc Hosp, Baiziting42, Nanjing, Jiangsu, Peoples R China

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 10期

基金：

中国国家自然科学基金;

关键词：

miRNAs; Cisplatin; Drug resistance; Breast; MITOCHONDRIAL TRANSCRIPTION FACTOR; NF-KAPPA-B; LET-7 MICRORNA FAMILY; MOBILITY GROUP A2; DRUG-RESISTANCE; CELL-CYCLE; OVARIAN-CANCER; DNA-DAMAGE; MULTIDRUG-RESISTANCE; COLORECTAL-CANCER;

D O I：

10.1007/s13277-016-5216-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin is a widely used chemotherapeutic agent in breast cancer treatments with inevitable rapidly acquired resistance or intrinsically resistance. Enormous evidence points to the bioprocesses of resistant formation consisting of diverse miRNAs direct and indirect actions on relevant encoding genes. In this report, we overview detailed information on the miRNAs effect on cisplatin-induced resistance, including alterations in cell survival, modification of DNA damage response, changes in cellular uptake or efflux of the drug, altered DNA methylation, and perturbations in the miRNA biogenesis pathway. This will provide potential miRNA-targeted strategies for the treatment of breast cancer therapy and requires further clinical application.

引用

页码：12905 / 12913

页数：9

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